ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Low affinity immunoglobulin gamma Fc region receptor II-c

Intramolecular
Cysteine 71 and cysteine 113
Cysteine 152 and cysteine 196
A redox-regulated disulphide may form within Low affinity immunoglobulin gamma Fc region receptor II-c between cysteines 71 and 113 (26 and 68 respectively in this structure).

Details

Redox score ?
84
PDB code
3wjl
Structure name
crystal structure of iib selective fc variant, fc(v12), in complex with fcgriib
Structure deposition date
2013-10-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31995
Residue number A
71
Residue number B
113
Peptide name
Low affinity immunoglobulin gamma Fc region receptor II-c

Ligandability

Cysteine 71 of Low affinity immunoglobulin gamma Fc region receptor II-c

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 113 of Low affinity immunoglobulin gamma Fc region receptor II-c

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Low affinity immunoglobulin gamma Fc region receptor II-c between cysteines 152 and 196 (107 and 151 respectively in this structure).

Details

Redox score ?
79
PDB code
3wjl
Structure name
crystal structure of iib selective fc variant, fc(v12), in complex with fcgriib
Structure deposition date
2013-10-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
91
Minimum pKa ?
nan
% buried
nan
Peptide accession
P31995
Residue number A
152
Residue number B
196
Peptide name
Low affinity immunoglobulin gamma Fc region receptor II-c

Ligandability

Cysteine 152 of Low affinity immunoglobulin gamma Fc region receptor II-c

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 196 of Low affinity immunoglobulin gamma Fc region receptor II-c

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: