C-C chemokine receptor type 7
Intramolecular
Cysteine 129 and cysteine 210
Cysteine 319 and cysteine 320
Cysteine 69 and cysteine 320
Cysteine 149 and cysteine 179
Cysteine 316 and cysteine 319
Cysteine 69 and cysteine 316
Cysteine 316 and cysteine 320
Cysteine 69 and cysteine 319
Cysteine 149 and cysteine 242
6qzh A 129 A 210
A redox-regulated disulphide may form within C-C chemokine receptor type 7 between cysteines 129 and 210.
Details
Redox score ?
85
PDB code
6qzh
Structure name
structure of the human cc chemokine receptor 7 in complex with the intracellular allosteric antagonist cmp2105 and the insertion protein sialidase nana
Structure deposition date
2019-03-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P32248
Residue number A
129
Residue number B
210
Peptide name
C-C chemokine receptor type 7
Ligandability
Cysteine 129 of C-C chemokine receptor type 7
Cysteine 210 of C-C chemokine receptor type 7
6qzh A 319 A 320
A redox-regulated disulphide may form within C-C chemokine receptor type 7 between cysteines 319 and 320. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
6qzh
Structure name
structure of the human cc chemokine receptor 7 in complex with the intracellular allosteric antagonist cmp2105 and the insertion protein sialidase nana
Structure deposition date
2019-03-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
83
Minimum pKa ?
11
% buried
79
Peptide accession
P32248
Residue number A
319
Residue number B
320
Peptide name
C-C chemokine receptor type 7
Ligandability
Cysteine 319 of C-C chemokine receptor type 7
Cysteine 320 of C-C chemokine receptor type 7
6qzh A 69 A 320
A redox-regulated disulphide may form within C-C chemokine receptor type 7 between cysteines 69 and 320. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
6qzh
Structure name
structure of the human cc chemokine receptor 7 in complex with the intracellular allosteric antagonist cmp2105 and the insertion protein sialidase nana
Structure deposition date
2019-03-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
73
Minimum pKa ?
11
% buried
51
Peptide accession
P32248
Residue number A
69
Residue number B
320
Peptide name
C-C chemokine receptor type 7
Ligandability
Cysteine 69 of C-C chemokine receptor type 7
Cysteine 320 of C-C chemokine receptor type 7
6qzh A 149 A 179
A redox-regulated disulphide may form within C-C chemokine receptor type 7 between cysteines 149 and 179. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
6qzh
Structure name
structure of the human cc chemokine receptor 7 in complex with the intracellular allosteric antagonist cmp2105 and the insertion protein sialidase nana
Structure deposition date
2019-03-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
69
Peptide accession
P32248
Residue number A
149
Residue number B
179
Peptide name
C-C chemokine receptor type 7
Ligandability
Cysteine 149 of C-C chemokine receptor type 7
Cysteine 179 of C-C chemokine receptor type 7
6qzh A 316 A 319
A redox-regulated disulphide may form within C-C chemokine receptor type 7 between cysteines 316 and 319. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
6qzh
Structure name
structure of the human cc chemokine receptor 7 in complex with the intracellular allosteric antagonist cmp2105 and the insertion protein sialidase nana
Structure deposition date
2019-03-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
88
Minimum pKa ?
13
% buried
100
Peptide accession
P32248
Residue number A
316
Residue number B
319
Peptide name
C-C chemokine receptor type 7
Ligandability
Cysteine 316 of C-C chemokine receptor type 7
Cysteine 319 of C-C chemokine receptor type 7
6qzh A 69 A 316
A redox-regulated disulphide may form within C-C chemokine receptor type 7 between cysteines 69 and 316. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
6qzh
Structure name
structure of the human cc chemokine receptor 7 in complex with the intracellular allosteric antagonist cmp2105 and the insertion protein sialidase nana
Structure deposition date
2019-03-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
11
% buried
72
Peptide accession
P32248
Residue number A
69
Residue number B
316
Peptide name
C-C chemokine receptor type 7
Ligandability
Cysteine 69 of C-C chemokine receptor type 7
Cysteine 316 of C-C chemokine receptor type 7
6qzh A 316 A 320
A redox-regulated disulphide may form within C-C chemokine receptor type 7 between cysteines 316 and 320. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
6qzh
Structure name
structure of the human cc chemokine receptor 7 in complex with the intracellular allosteric antagonist cmp2105 and the insertion protein sialidase nana
Structure deposition date
2019-03-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
79
Peptide accession
P32248
Residue number A
316
Residue number B
320
Peptide name
C-C chemokine receptor type 7
Ligandability
Cysteine 316 of C-C chemokine receptor type 7
Cysteine 320 of C-C chemokine receptor type 7
6qzh A 69 A 319
A redox-regulated disulphide may form within C-C chemokine receptor type 7 between cysteines 69 and 319. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
6qzh
Structure name
structure of the human cc chemokine receptor 7 in complex with the intracellular allosteric antagonist cmp2105 and the insertion protein sialidase nana
Structure deposition date
2019-03-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
11
% buried
72
Peptide accession
P32248
Residue number A
69
Residue number B
319
Peptide name
C-C chemokine receptor type 7
Ligandability
Cysteine 69 of C-C chemokine receptor type 7
Cysteine 319 of C-C chemokine receptor type 7
6qzh A 149 A 242
A redox-regulated disulphide may form within C-C chemokine receptor type 7 between cysteines 149 and 242. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
6qzh
Structure name
structure of the human cc chemokine receptor 7 in complex with the intracellular allosteric antagonist cmp2105 and the insertion protein sialidase nana
Structure deposition date
2019-03-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
52
Peptide accession
P32248
Residue number A
149
Residue number B
242
Peptide name
C-C chemokine receptor type 7
Ligandability
Cysteine 149 of C-C chemokine receptor type 7
Cysteine 242 of C-C chemokine receptor type 7
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