G-protein coupled receptor 183
Intramolecular
Cysteine 104 and cysteine 181
Cysteine 124 and cysteine 152
Cysteine 220 and cysteine 221
Cysteine 301 and cysteine 302
Cysteine 295 and cysteine 302
Cysteine 256 and cysteine 302
Cysteine 256 and cysteine 295
7tuy R 104 R 181
A redox-regulated disulphide may form within G-protein coupled receptor 183 between cysteines 104 and 181.
Details
Redox score ?
86
PDB code
7tuy
Structure name
cryo-em structure of gsk682753a-bound ebi2/gpr183
Structure deposition date
2022-02-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P32249
Residue number A
104
Residue number B
181
Peptide name
G-protein coupled receptor 183
Ligandability
Cysteine 104 of G-protein coupled receptor 183
Cysteine 181 of G-protein coupled receptor 183
7tuz R 124 R 152
A redox-regulated disulphide may form within G-protein coupled receptor 183 between cysteines 124 and 152. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
7tuz
Structure name
cryo-em structure of 7alpha,25-dihydroxycholesterol-bound ebi2/gpr183 in complex with gi protein
Structure deposition date
2022-02-03
Thiol separation (Å)
6
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
68
Peptide accession
P32249
Residue number A
124
Residue number B
152
Peptide name
G-protein coupled receptor 183
Ligandability
Cysteine 124 of G-protein coupled receptor 183
Cysteine 152 of G-protein coupled receptor 183
7tuz R 220 R 221
A redox-regulated disulphide may form within G-protein coupled receptor 183 between cysteines 220 and 221. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
7tuz
Structure name
cryo-em structure of 7alpha,25-dihydroxycholesterol-bound ebi2/gpr183 in complex with gi protein
Structure deposition date
2022-02-03
Thiol separation (Å)
7
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
22
Peptide accession
P32249
Residue number A
220
Residue number B
221
Peptide name
G-protein coupled receptor 183
Ligandability
Cysteine 220 of G-protein coupled receptor 183
Cysteine 221 of G-protein coupled receptor 183
7tuy R 291 R 292
A redox-regulated disulphide may form within G-protein coupled receptor 183 between cysteines 301 and 302 (291 and 292 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
7tuy
Structure name
cryo-em structure of gsk682753a-bound ebi2/gpr183
Structure deposition date
2022-02-03
Thiol separation (Å)
6
Half-sphere exposure sum ?
82
Minimum pKa ?
12
% buried
84
Peptide accession
P32249
Residue number A
301
Residue number B
302
Peptide name
G-protein coupled receptor 183
Ligandability
Cysteine 301 of G-protein coupled receptor 183
Cysteine 302 of G-protein coupled receptor 183
7tuz R 295 R 302
A redox-regulated disulphide may form within G-protein coupled receptor 183 between cysteines 295 and 302. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
7tuz
Structure name
cryo-em structure of 7alpha,25-dihydroxycholesterol-bound ebi2/gpr183 in complex with gi protein
Structure deposition date
2022-02-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
56
Peptide accession
P32249
Residue number A
295
Residue number B
302
Peptide name
G-protein coupled receptor 183
Ligandability
Cysteine 295 of G-protein coupled receptor 183
Cysteine 302 of G-protein coupled receptor 183
7tuz R 256 R 302
A redox-regulated disulphide may form within G-protein coupled receptor 183 between cysteines 256 and 302. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7tuz
Structure name
cryo-em structure of 7alpha,25-dihydroxycholesterol-bound ebi2/gpr183 in complex with gi protein
Structure deposition date
2022-02-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
11
% buried
67
Peptide accession
P32249
Residue number A
256
Residue number B
302
Peptide name
G-protein coupled receptor 183
Ligandability
Cysteine 256 of G-protein coupled receptor 183
Cysteine 302 of G-protein coupled receptor 183
7tuz R 256 R 295
A redox-regulated disulphide may form within G-protein coupled receptor 183 between cysteines 256 and 295. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
7tuz
Structure name
cryo-em structure of 7alpha,25-dihydroxycholesterol-bound ebi2/gpr183 in complex with gi protein
Structure deposition date
2022-02-03
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
11
% buried
60
Peptide accession
P32249
Residue number A
256
Residue number B
295
Peptide name
G-protein coupled receptor 183
Ligandability
Cysteine 256 of G-protein coupled receptor 183
Cysteine 295 of G-protein coupled receptor 183
If this tool was useful for finding a disulphide, please cite: