ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Sodium/calcium exchanger 1

Intermolecular
Cysteine 517 and cysteine 517
Intramolecular
Cysteine 415 and cysteine 419
A redox-regulated disulphide may form between two units of Sodium/calcium exchanger 1 at cysteines 517 and 517 (485 and 485 respectively in this structure).

Details

Redox score ?
78
PDB code
3gin
Structure name
crystal structure of e454k-cbd1
Structure deposition date
2009-03-05
Thiol separation (Å)
3
Half-sphere exposure sum ?
81
Minimum pKa ?
7
% buried
58
Peptide A name
Sodium/calcium exchanger 1
Peptide B name
Sodium/calcium exchanger 1
Peptide A accession
P23685
Peptide B accession
P23685
Peptide A residue number
517
Peptide B residue number
517

Ligandability

A redox-regulated disulphide may form within Sodium/calcium exchanger 1 between cysteines 415 and 419 (383 and 387 respectively in this structure).

Details

Redox score ?
78
PDB code
3gin
Structure name
crystal structure of e454k-cbd1
Structure deposition date
2009-03-05
Thiol separation (Å)
3
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
39
Peptide accession
P23685
Residue number A
415
Residue number B
419
Peptide name
Sodium/calcium exchanger 1

Ligandability

Cysteine 415 of Sodium/calcium exchanger 1

Cysteine 419 of Sodium/calcium exchanger 1

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