a tool for identifying drug-targetable redox-active disulphides

Guanylate-binding protein 2

Intramolecular

Cysteine 404 and cysteine 405

A redox-regulated disulphide may form within Guanylate-binding protein 2 between cysteines 404 and 405.

Details

Redox score ?

66

PDB code

Structure name

crystal structure of human guanylate-binding protein 2 (hgbp2) k51a mutant

Structure deposition date

2021-03-15

Thiol separation (Å)

5

Half-sphere exposure sum ?

63

Minimum pK_a ?

9

% buried

26

Peptide accession

Residue number A

404

Residue number B

405

Peptide name

Guanylate-binding protein 2

Ligandability

Cysteine 404 of Guanylate-binding protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 405 of Guanylate-binding protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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