ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Interferon alpha-8

Intramolecular
Cysteine 24 and cysteine 122
Cysteine 52 and cysteine 162
A redox-regulated disulphide may form within Interferon alpha-8 between cysteines 24 and 122 (1 and 99 respectively in this structure).

Details

Redox score ?
89
PDB code
6jhd
Structure name
solution structure of ifn alpha8
Structure deposition date
2019-02-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P32881
Residue number A
24
Residue number B
122
Peptide name
Interferon alpha-8

Ligandability

Cysteine 24 of Interferon alpha-8

Cysteine 122 of Interferon alpha-8

A redox-regulated disulphide may form within Interferon alpha-8 between cysteines 52 and 162 (29 and 139 respectively in this structure).

Details

Redox score ?
87
PDB code
6jhd
Structure name
solution structure of ifn alpha8
Structure deposition date
2019-02-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P32881
Residue number A
52
Residue number B
162
Peptide name
Interferon alpha-8

Ligandability

Cysteine 52 of Interferon alpha-8

Cysteine 162 of Interferon alpha-8

If this tool was useful for finding a disulphide, please cite: