a tool for identifying drug-targetable redox-active disulphides

Desmoglein-3

Intramolecular

Cysteine 251 and cysteine 253

A redox-regulated disulphide may form within Desmoglein-3 between cysteines 251 and 253 (202 and 204 respectively in this structure).

Details

Redox score ?

73

PDB code

Structure name

crystal structure of human desmoglein-3 ectodomain

Structure deposition date

2015-11-13

Thiol separation (Å)

4

Half-sphere exposure sum ?

65

Minimum pK_a ?

8

% buried

56

Peptide accession

Residue number A

251

Residue number B

253

Peptide name

Desmoglein-3

Ligandability

Cysteine 251 of Desmoglein-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 253 of Desmoglein-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: