ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cytokine receptor common subunit beta

Intramolecular
Cysteine 75 and cysteine 96
Cysteine 289 and cysteine 306
Cysteine 250 and cysteine 260
Cysteine 35 and cysteine 45
Cysteine 86 and cysteine 91
Cysteine 45 and cysteine 96
Cysteine 260 and cysteine 289
Cysteine 35 and cysteine 96
Cysteine 45 and cysteine 75
Cysteine 35 and cysteine 75
More...
Cysteine 250 and cysteine 289
Cysteine 250 and cysteine 306
Cysteine 260 and cysteine 306
A redox-regulated disulphide may form within Cytokine receptor common subunit beta between cysteines 75 and 96.

Details

Redox score ?
89
PDB code
6nmy
Structure name
a cytokine-receptor complex
Structure deposition date
2019-01-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P32927
Residue number A
75
Residue number B
96
Peptide name
Cytokine receptor common subunit beta

Ligandability

Cysteine 75 of Cytokine receptor common subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 96 of Cytokine receptor common subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytokine receptor common subunit beta between cysteines 289 and 306.

Details

Redox score ?
86
PDB code
6nmy
Structure name
a cytokine-receptor complex
Structure deposition date
2019-01-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P32927
Residue number A
289
Residue number B
306
Peptide name
Cytokine receptor common subunit beta

Ligandability

Cysteine 289 of Cytokine receptor common subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 306 of Cytokine receptor common subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytokine receptor common subunit beta between cysteines 250 and 260 (226 and 236 respectively in this structure).

Details

Redox score ?
83
PDB code
1gh7
Structure name
crystal structure of the complete extracellular domain of the beta- common receptor of il-3, il-5, and gm-csf
Structure deposition date
2000-11-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P32927
Residue number A
250
Residue number B
260
Peptide name
Cytokine receptor common subunit beta

Ligandability

Cysteine 250 of Cytokine receptor common subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 260 of Cytokine receptor common subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytokine receptor common subunit beta between cysteines 35 and 45.

Details

Redox score ?
80
PDB code
6nmy
Structure name
a cytokine-receptor complex
Structure deposition date
2019-01-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
P32927
Residue number A
35
Residue number B
45
Peptide name
Cytokine receptor common subunit beta

Ligandability

Cysteine 35 of Cytokine receptor common subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 45 of Cytokine receptor common subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytokine receptor common subunit beta between cysteines 86 and 91.

Details

Redox score ?
79
PDB code
5dwu
Structure name
beta common receptor in complex with a fab
Structure deposition date
2015-09-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
4
Peptide accession
P32927
Residue number A
86
Residue number B
91
Peptide name
Cytokine receptor common subunit beta

Ligandability

Cysteine 86 of Cytokine receptor common subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 91 of Cytokine receptor common subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytokine receptor common subunit beta between cysteines 45 and 96 (21 and 72 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
1gh7
Structure name
crystal structure of the complete extracellular domain of the beta- common receptor of il-3, il-5, and gm-csf
Structure deposition date
2000-11-27
Thiol separation (Å)
6
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P32927
Residue number A
45
Residue number B
96
Peptide name
Cytokine receptor common subunit beta

Ligandability

Cysteine 45 of Cytokine receptor common subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 96 of Cytokine receptor common subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytokine receptor common subunit beta between cysteines 260 and 289 (236 and 271 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
1gh7
Structure name
crystal structure of the complete extracellular domain of the beta- common receptor of il-3, il-5, and gm-csf
Structure deposition date
2000-11-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P32927
Residue number A
260
Residue number B
289
Peptide name
Cytokine receptor common subunit beta

Ligandability

Cysteine 260 of Cytokine receptor common subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 289 of Cytokine receptor common subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytokine receptor common subunit beta between cysteines 35 and 96. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
4nkq
Structure name
structure of a cytokine receptor complex
Structure deposition date
2013-11-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P32927
Residue number A
35
Residue number B
96
Peptide name
Cytokine receptor common subunit beta

Ligandability

Cysteine 35 of Cytokine receptor common subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 96 of Cytokine receptor common subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytokine receptor common subunit beta between cysteines 45 and 75. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
6nmy
Structure name
a cytokine-receptor complex
Structure deposition date
2019-01-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P32927
Residue number A
45
Residue number B
75
Peptide name
Cytokine receptor common subunit beta

Ligandability

Cysteine 45 of Cytokine receptor common subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 75 of Cytokine receptor common subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytokine receptor common subunit beta between cysteines 35 and 75 (11 and 51 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
1gh7
Structure name
crystal structure of the complete extracellular domain of the beta- common receptor of il-3, il-5, and gm-csf
Structure deposition date
2000-11-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P32927
Residue number A
35
Residue number B
75
Peptide name
Cytokine receptor common subunit beta

Ligandability

Cysteine 35 of Cytokine receptor common subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 75 of Cytokine receptor common subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytokine receptor common subunit beta between cysteines 250 and 289. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
6nmy
Structure name
a cytokine-receptor complex
Structure deposition date
2019-01-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P32927
Residue number A
250
Residue number B
289
Peptide name
Cytokine receptor common subunit beta

Ligandability

Cysteine 250 of Cytokine receptor common subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 289 of Cytokine receptor common subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytokine receptor common subunit beta between cysteines 250 and 306. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
4nkq
Structure name
structure of a cytokine receptor complex
Structure deposition date
2013-11-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P32927
Residue number A
250
Residue number B
306
Peptide name
Cytokine receptor common subunit beta

Ligandability

Cysteine 250 of Cytokine receptor common subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 306 of Cytokine receptor common subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytokine receptor common subunit beta between cysteines 260 and 306. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
5dwu
Structure name
beta common receptor in complex with a fab
Structure deposition date
2015-09-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P32927
Residue number A
260
Residue number B
306
Peptide name
Cytokine receptor common subunit beta

Ligandability

Cysteine 260 of Cytokine receptor common subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 306 of Cytokine receptor common subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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