ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Intercellular adhesion molecule 3

Intramolecular
Cysteine 57 and cysteine 100
Cysteine 53 and cysteine 96
A redox-regulated disulphide may form within Intercellular adhesion molecule 3 between cysteines 57 and 100 (28 and 71 respectively in this structure).

Details

Redox score ?
88
PDB code
1t0p
Structure name
structural basis of icam recognition by integrin alpahlbeta2 revealed in the complex structure of binding domains of icam-3 and alphalbeta2 at 1
Structure deposition date
2004-04-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P32942
Residue number A
57
Residue number B
100
Peptide name
Intercellular adhesion molecule 3

Ligandability

Cysteine 57 of Intercellular adhesion molecule 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 of Intercellular adhesion molecule 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Intercellular adhesion molecule 3 between cysteines 53 and 96 (24 and 67 respectively in this structure).

Details

Redox score ?
81
PDB code
1t0p
Structure name
structural basis of icam recognition by integrin alpahlbeta2 revealed in the complex structure of binding domains of icam-3 and alphalbeta2 at 1
Structure deposition date
2004-04-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P32942
Residue number A
53
Residue number B
96
Peptide name
Intercellular adhesion molecule 3

Ligandability

Cysteine 53 of Intercellular adhesion molecule 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 96 of Intercellular adhesion molecule 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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