Cytochrome P450 2C19

A redox-regulated disulphide may form within Cytochrome P450 2C19 between cysteines 164 and 486. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

4gqs

Structure name

structure of human microsomal cytochrome p450 (cyp) 2c19

Structure deposition date

2012-08-23

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

P33261

Residue number A

164

Residue number B

486

Peptide name

Cytochrome P450 2C19

Ligandability

Cysteine 164 of Cytochrome P450 2C19

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 486 of Cytochrome P450 2C19

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytochrome P450 2C19 between cysteines 172 and 175. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

4gqs

Structure name

structure of human microsomal cytochrome p450 (cyp) 2c19

Structure deposition date

2012-08-23

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

P33261

Residue number A

172

Residue number B

175

Peptide name

Cytochrome P450 2C19

Ligandability

Cysteine 172 of Cytochrome P450 2C19

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 175 of Cytochrome P450 2C19

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytochrome P450 2C19 between cysteines 172 and 179. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?