ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Multidrug resistance-associated protein 1

Intramolecular
Cysteine 375 and cysteine 1204
Cysteine 1204 and cysteine 1208
Cysteine 375 and cysteine 1208
A redox-regulated disulphide may form within Multidrug resistance-associated protein 1 between cysteines 375 and 1204. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
5uj9
Structure name
cryo-em structure of bovine multidrug resistance protein 1 (mrp1)
Structure deposition date
2017-01-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
47
Peptide accession
Q8HXQ5
Residue number A
375
Residue number B
1204
Peptide name
Multidrug resistance-associated protein 1

Ligandability

Cysteine 375 of Multidrug resistance-associated protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1204 of Multidrug resistance-associated protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Multidrug resistance-associated protein 1 between cysteines 1204 and 1208. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
6uy0
Structure name
cryo-em structure of wild-type bovine multidrug resistance protein 1 (mrp1) under active turnover conditions
Structure deposition date
2019-11-09
Thiol separation (Å)
7
Half-sphere exposure sum ?
52
Minimum pKa ?
9
% buried
27
Peptide accession
Q8HXQ5
Residue number A
1204
Residue number B
1208
Peptide name
Multidrug resistance-associated protein 1

Ligandability

Cysteine 1204 of Multidrug resistance-associated protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1208 of Multidrug resistance-associated protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Multidrug resistance-associated protein 1 between cysteines 375 and 1208. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
6uy0
Structure name
cryo-em structure of wild-type bovine multidrug resistance protein 1 (mrp1) under active turnover conditions
Structure deposition date
2019-11-09
Thiol separation (Å)
7
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
22
Peptide accession
Q8HXQ5
Residue number A
375
Residue number B
1208
Peptide name
Multidrug resistance-associated protein 1

Ligandability

Cysteine 375 of Multidrug resistance-associated protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1208 of Multidrug resistance-associated protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: