ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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T-lymphocyte activation antigen CD80

Intramolecular
Cysteine 50 and cysteine 116
Cysteine 162 and cysteine 216
A redox-regulated disulphide may form within T-lymphocyte activation antigen CD80 between cysteines 50 and 116 (16 and 82 respectively in this structure).

Details

Redox score ?
82
PDB code
1dr9
Structure name
crystal structure of a soluble form of b7-1 (cd80)
Structure deposition date
2000-01-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P33681
Residue number A
50
Residue number B
116
Peptide name
T-lymphocyte activation antigen CD80

Ligandability

Cysteine 50 of T-lymphocyte activation antigen CD80

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 116 of T-lymphocyte activation antigen CD80

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-lymphocyte activation antigen CD80 between cysteines 162 and 216 (128 and 182 respectively in this structure).

Details

Redox score ?
80
PDB code
1i8l
Structure name
human b7-1/ctla-4 co-stimulatory complex
Structure deposition date
2001-03-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P33681
Residue number A
162
Residue number B
216
Peptide name
T-lymphocyte activation antigen CD80

Ligandability

Cysteine 162 of T-lymphocyte activation antigen CD80

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of T-lymphocyte activation antigen CD80

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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