a tool for identifying drug-targetable redox-active disulphides

Protein S100-A5

Intermolecular

Cysteine 80 and cysteine 80

A redox-regulated disulphide may form between two units of Protein S100-A5 at cysteines 80 and 80 (79 and 79 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

41

PDB code

Structure name

2

Structure deposition date

2012-01-31

Thiol separation (Å)

8

Half-sphere exposure sum ?

72

Minimum pK_a ?

12

% buried

80

Peptide A name

Protein S100-A5

Peptide B name

Protein S100-A5

Peptide A accession

Peptide B accession

Peptide A residue number

80

Peptide B residue number

80

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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