ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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N-acetylgalactosamine-6-sulfatase

Intramolecular
Cysteine 489 and cysteine 518
Cysteine 501 and cysteine 507
Cysteine 308 and cysteine 419
A redox-regulated disulphide may form within N-acetylgalactosamine-6-sulfatase between cysteines 489 and 518.

Details

Redox score ?
87
PDB code
4fdj
Structure name
the molecular basis of mucopolysaccharidosis iv a, complex with galnac
Structure deposition date
2012-05-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P34059
Residue number A
489
Residue number B
518
Peptide name
N-acetylgalactosamine-6-sulfatase

Ligandability

Cysteine 489 of N-acetylgalactosamine-6-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 518 of N-acetylgalactosamine-6-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within N-acetylgalactosamine-6-sulfatase between cysteines 501 and 507.

Details

Redox score ?
87
PDB code
4fdj
Structure name
the molecular basis of mucopolysaccharidosis iv a, complex with galnac
Structure deposition date
2012-05-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
P34059
Residue number A
501
Residue number B
507
Peptide name
N-acetylgalactosamine-6-sulfatase

Ligandability

Cysteine 501 of N-acetylgalactosamine-6-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 507 of N-acetylgalactosamine-6-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within N-acetylgalactosamine-6-sulfatase between cysteines 308 and 419.

Details

Redox score ?
77
PDB code
4fdj
Structure name
the molecular basis of mucopolysaccharidosis iv a, complex with galnac
Structure deposition date
2012-05-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
P34059
Residue number A
308
Residue number B
419
Peptide name
N-acetylgalactosamine-6-sulfatase

Ligandability

Cysteine 308 of N-acetylgalactosamine-6-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 419 of N-acetylgalactosamine-6-sulfatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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