Tyrosine-protein kinase RYK

Intramolecular

A redox-regulated disulphide may form within Tyrosine-protein kinase RYK between cysteines 577 and 578. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

6tua

Structure name

the ryk pseudokinase domain

Structure deposition date

2020-01-04

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

P34925

Residue number A

577

Residue number B

578

Peptide name

Tyrosine-protein kinase RYK

Ligandability

Cysteine 577 of Tyrosine-protein kinase RYK

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 578 of Tyrosine-protein kinase RYK

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein kinase RYK between cysteines 577 and 595. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

6tua

Structure name

the ryk pseudokinase domain

Structure deposition date

2020-01-04

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

P34925

Residue number A

577

Residue number B

595

Peptide name

Tyrosine-protein kinase RYK

Ligandability

Cysteine 577 of Tyrosine-protein kinase RYK

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 595 of Tyrosine-protein kinase RYK

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein kinase RYK between cysteines 578 and 595. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?