G protein-coupled receptor kinase 5
Intramolecular
Cysteine 214 and cysteine 260
Cysteine 201 and cysteine 214 L
Cysteine 203 and cysteine 214 L
Cysteine 201 and cysteine 203 L
Cysteine 201 and cysteine 260 L
Cysteine 54 and cysteine 57
Cysteine 203 and cysteine 260 L
Cysteine 57 and cysteine 71
Cysteine 201 and cysteine 474 L
Cysteine 71 and cysteine 79
Cysteine 373 and cysteine 420
4tnb A 214 A 260
A redox-regulated disulphide may form within G protein-coupled receptor kinase 5 between cysteines 214 and 260.
Details
Redox score ?
68
PDB code
4tnb
Structure name
crystal structure of g protein-coupled receptor kinase 5 in complex with sangivamycin
Structure deposition date
2014-06-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
92
Minimum pKa ?
9
% buried
100
Peptide accession
P34947
Residue number A
214
Residue number B
260
Peptide name
G protein-coupled receptor kinase 5
Ligandability
Cysteine 214 of G protein-coupled receptor kinase 5
Cysteine 260 of G protein-coupled receptor kinase 5
6pjx A 201 A 214
A redox-regulated disulphide may form within G protein-coupled receptor kinase 5 between cysteines 201 and 214. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
6pjx
Structure name
crystal structure of g protein-coupled receptor kinase 5 (grk5) in complex with calmodulin (cam)
Structure deposition date
2019-06-28
Thiol separation (Å)
5
Half-sphere exposure sum ?
78
Minimum pKa ?
10
% buried
98
Peptide accession
P34947
Residue number A
201
Residue number B
214
Peptide name
G protein-coupled receptor kinase 5
Ligandability
Cysteine 201 of G protein-coupled receptor kinase 5
Cysteine 214 of G protein-coupled receptor kinase 5
4tnb A 203 A 214
A redox-regulated disulphide may form within G protein-coupled receptor kinase 5 between cysteines 203 and 214. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
4tnb
Structure name
crystal structure of g protein-coupled receptor kinase 5 in complex with sangivamycin
Structure deposition date
2014-06-03
Thiol separation (Å)
5
Half-sphere exposure sum ?
89
Minimum pKa ?
10
% buried
100
Peptide accession
P34947
Residue number A
203
Residue number B
214
Peptide name
G protein-coupled receptor kinase 5
Ligandability
Cysteine 203 of G protein-coupled receptor kinase 5
Cysteine 214 of G protein-coupled receptor kinase 5
4tnb A 201 A 203
A redox-regulated disulphide may form within G protein-coupled receptor kinase 5 between cysteines 201 and 203. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
4tnb
Structure name
crystal structure of g protein-coupled receptor kinase 5 in complex with sangivamycin
Structure deposition date
2014-06-03
Thiol separation (Å)
6
Half-sphere exposure sum ?
86
Minimum pKa ?
8
% buried
96
Peptide accession
P34947
Residue number A
201
Residue number B
203
Peptide name
G protein-coupled receptor kinase 5
Ligandability
Cysteine 201 of G protein-coupled receptor kinase 5
Cysteine 203 of G protein-coupled receptor kinase 5
4tnd A 201 A 260
A redox-regulated disulphide may form within G protein-coupled receptor kinase 5 between cysteines 201 and 260. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
4tnd
Structure name
crystal structure of g protein-coupled receptor kinase 5 in complex with amp-pnp
Structure deposition date
2014-06-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
88
Minimum pKa ?
8
% buried
96
Peptide accession
P34947
Residue number A
201
Residue number B
260
Peptide name
G protein-coupled receptor kinase 5
Ligandability
Cysteine 201 of G protein-coupled receptor kinase 5
Cysteine 260 of G protein-coupled receptor kinase 5
4tnd A 54 A 57
A redox-regulated disulphide may form within G protein-coupled receptor kinase 5 between cysteines 54 and 57. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
4tnd
Structure name
crystal structure of g protein-coupled receptor kinase 5 in complex with amp-pnp
Structure deposition date
2014-06-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
50
Peptide accession
P34947
Residue number A
54
Residue number B
57
Peptide name
G protein-coupled receptor kinase 5
Ligandability
Cysteine 54 of G protein-coupled receptor kinase 5
Cysteine 57 of G protein-coupled receptor kinase 5
4wnk A 203 A 260
A redox-regulated disulphide may form within G protein-coupled receptor kinase 5 between cysteines 203 and 260. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
4wnk
Structure name
crystal structure of bovine g protein coupled-receptor kinase 5 in complex with ccg215022
Structure deposition date
2014-10-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
8
% buried
88
Peptide accession
P43249
Residue number A
203
Residue number B
260
Peptide name
G protein-coupled receptor kinase 5
Ligandability
Cysteine 203 of G protein-coupled receptor kinase 5
Cysteine 260 of G protein-coupled receptor kinase 5
4tnb A 57 A 71
A redox-regulated disulphide may form within G protein-coupled receptor kinase 5 between cysteines 57 and 71. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
4tnb
Structure name
crystal structure of g protein-coupled receptor kinase 5 in complex with sangivamycin
Structure deposition date
2014-06-03
Thiol separation (Å)
8
Half-sphere exposure sum ?
63
Minimum pKa ?
12
% buried
84
Peptide accession
P34947
Residue number A
57
Residue number B
71
Peptide name
G protein-coupled receptor kinase 5
Ligandability
Cysteine 57 of G protein-coupled receptor kinase 5
Cysteine 71 of G protein-coupled receptor kinase 5
4tnd A 201 A 474
A redox-regulated disulphide may form within G protein-coupled receptor kinase 5 between cysteines 201 and 474. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
4tnd
Structure name
crystal structure of g protein-coupled receptor kinase 5 in complex with amp-pnp
Structure deposition date
2014-06-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
58
Minimum pKa ?
8
% buried
46
Peptide accession
P34947
Residue number A
201
Residue number B
474
Peptide name
G protein-coupled receptor kinase 5
Ligandability
Cysteine 201 of G protein-coupled receptor kinase 5
Cysteine 474 of G protein-coupled receptor kinase 5
4tnb A 71 A 79
A redox-regulated disulphide may form within G protein-coupled receptor kinase 5 between cysteines 71 and 79. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
4tnb
Structure name
crystal structure of g protein-coupled receptor kinase 5 in complex with sangivamycin
Structure deposition date
2014-06-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
59
Peptide accession
P34947
Residue number A
71
Residue number B
79
Peptide name
G protein-coupled receptor kinase 5
Ligandability
Cysteine 71 of G protein-coupled receptor kinase 5
Cysteine 79 of G protein-coupled receptor kinase 5
4wnk A 373 A 420
A redox-regulated disulphide may form within G protein-coupled receptor kinase 5 between cysteines 373 and 420. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
28
PDB code
4wnk
Structure name
crystal structure of bovine g protein coupled-receptor kinase 5 in complex with ccg215022
Structure deposition date
2014-10-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
13
% buried
100
Peptide accession
P43249
Residue number A
373
Residue number B
420
Peptide name
G protein-coupled receptor kinase 5
Ligandability
Cysteine 373 of G protein-coupled receptor kinase 5
Cysteine 420 of G protein-coupled receptor kinase 5
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