Cannabinoid receptor 2
Intermolecular
Cysteine 351 of Guanine nucleotide-binding protein G(i) subunit alpha-1 and cysteine 134
Intramolecular
Cysteine 174 and cysteine 179
Cysteine 174 and cysteine 175
Cysteine 175 and cysteine 179
Cysteine 257 and cysteine 288
Cysteine 284 and cysteine 288
Cysteine 40 and cysteine 89
6kpf A 351 R 134
A redox-regulated disulphide may form between cysteine 351 of Guanine nucleotide-binding protein G(i) subunit alpha-1 and cysteine 134 of Cannabinoid receptor 2.
Details
Redox score ?
71
PDB code
6kpf
Structure name
cryo-em structure of a class a gpcr with g protein complex
Structure deposition date
2019-08-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
80
Minimum pKa ?
8
% buried
100
Peptide A name
Guanine nucleotide-binding protein G(i) subunit alpha-1
Peptide B name
Cannabinoid receptor 2
Peptide A accession
P63096
Peptide B accession
P34972
Peptide A residue number
351
Peptide B residue number
134
Ligandability
Cysteine 351 of Guanine nucleotide-binding protein G(i) subunit alpha-1
Cysteine 134 of Cannabinoid receptor 2
6kpc A 174 A 179
A redox-regulated disulphide may form within Cannabinoid receptor 2 between cysteines 174 and 179.
Details
Redox score ?
86
PDB code
6kpc
Structure name
crystal structure of an agonist bound gpcr
Structure deposition date
2019-08-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P34972
Residue number A
174
Residue number B
179
Peptide name
Cannabinoid receptor 2
Ligandability
Cysteine 174 of Cannabinoid receptor 2
Cysteine 179 of Cannabinoid receptor 2
6kpc A 174 A 175
A redox-regulated disulphide may form within Cannabinoid receptor 2 between cysteines 174 and 175.
Details
Redox score ?
60
PDB code
6kpc
Structure name
crystal structure of an agonist bound gpcr
Structure deposition date
2019-08-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
42
Minimum pKa ?
8
% buried
nan
Peptide accession
P34972
Residue number A
174
Residue number B
175
Peptide name
Cannabinoid receptor 2
Ligandability
Cysteine 174 of Cannabinoid receptor 2
Cysteine 175 of Cannabinoid receptor 2
6kpc A 175 A 179
A redox-regulated disulphide may form within Cannabinoid receptor 2 between cysteines 175 and 179. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
6kpc
Structure name
crystal structure of an agonist bound gpcr
Structure deposition date
2019-08-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
44
Minimum pKa ?
8
% buried
nan
Peptide accession
P34972
Residue number A
175
Residue number B
179
Peptide name
Cannabinoid receptor 2
Ligandability
Cysteine 175 of Cannabinoid receptor 2
Cysteine 179 of Cannabinoid receptor 2
6kpc A 257 A 288
A redox-regulated disulphide may form within Cannabinoid receptor 2 between cysteines 257 and 288. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
6kpc
Structure name
crystal structure of an agonist bound gpcr
Structure deposition date
2019-08-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
74
Peptide accession
P34972
Residue number A
257
Residue number B
288
Peptide name
Cannabinoid receptor 2
Ligandability
Cysteine 257 of Cannabinoid receptor 2
Cysteine 288 of Cannabinoid receptor 2
6kpc A 284 A 288
A redox-regulated disulphide may form within Cannabinoid receptor 2 between cysteines 284 and 288. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
6kpc
Structure name
crystal structure of an agonist bound gpcr
Structure deposition date
2019-08-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
68
Peptide accession
P34972
Residue number A
284
Residue number B
288
Peptide name
Cannabinoid receptor 2
Ligandability
Cysteine 284 of Cannabinoid receptor 2
Cysteine 288 of Cannabinoid receptor 2
6kpc A 40 A 89
A redox-regulated disulphide may form within Cannabinoid receptor 2 between cysteines 40 and 89. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
6kpc
Structure name
crystal structure of an agonist bound gpcr
Structure deposition date
2019-08-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
9
% buried
50
Peptide accession
P34972
Residue number A
40
Residue number B
89
Peptide name
Cannabinoid receptor 2
Ligandability
Cysteine 40 of Cannabinoid receptor 2
Cysteine 89 of Cannabinoid receptor 2
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