ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Thyrotropin-releasing hormone receptor

Intramolecular
Cysteine 98 and cysteine 179
Cysteine 305 and cysteine 308
Cysteine 98 and cysteine 100
A redox-regulated disulphide may form within Thyrotropin-releasing hormone receptor between cysteines 98 and 179. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
7wkd
Structure name
trh-trhr g protein complex
Structure deposition date
2022-01-09
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
11
% buried
58
Peptide accession
P34981
Residue number A
98
Residue number B
179
Peptide name
Thyrotropin-releasing hormone receptor

Ligandability

Cysteine 98 of Thyrotropin-releasing hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 179 of Thyrotropin-releasing hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyrotropin-releasing hormone receptor between cysteines 305 and 308. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
7wkd
Structure name
trh-trhr g protein complex
Structure deposition date
2022-01-09
Thiol separation (Å)
6
Half-sphere exposure sum ?
58
Minimum pKa ?
11
% buried
50
Peptide accession
P34981
Residue number A
305
Residue number B
308
Peptide name
Thyrotropin-releasing hormone receptor

Ligandability

Cysteine 305 of Thyrotropin-releasing hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 308 of Thyrotropin-releasing hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyrotropin-releasing hormone receptor between cysteines 98 and 100. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7wkd
Structure name
trh-trhr g protein complex
Structure deposition date
2022-01-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
22
Peptide accession
P34981
Residue number A
98
Residue number B
100
Peptide name
Thyrotropin-releasing hormone receptor

Ligandability

Cysteine 98 of Thyrotropin-releasing hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 of Thyrotropin-releasing hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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