ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Prostaglandin-E(2) 9-reductase

Intramolecular
Cysteine 188 and cysteine 206
Cysteine 193 and cysteine 206
A redox-regulated disulphide may form within Prostaglandin-E(2) 9-reductase between cysteines 188 and 206. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
1q13
Structure name
crystal structure of rabbit 20alpha hyroxysteroid dehydrogenase in ternary complex with nadp and testosterone
Structure deposition date
2003-07-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
96
Peptide accession
P80508
Residue number A
188
Residue number B
206
Peptide name
Prostaglandin-E(2) 9-reductase

Ligandability

Cysteine 188 of Prostaglandin-E(2) 9-reductase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 206 of Prostaglandin-E(2) 9-reductase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prostaglandin-E(2) 9-reductase between cysteines 193 and 206. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
1q13
Structure name
crystal structure of rabbit 20alpha hyroxysteroid dehydrogenase in ternary complex with nadp and testosterone
Structure deposition date
2003-07-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
79
Minimum pKa ?
11
% buried
96
Peptide accession
P80508
Residue number A
193
Residue number B
206
Peptide name
Prostaglandin-E(2) 9-reductase

Ligandability

Cysteine 193 of Prostaglandin-E(2) 9-reductase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 206 of Prostaglandin-E(2) 9-reductase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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