Trypsin-3
Intermolecular
Cysteine 121 and cysteine 49 of Pancreatic trypsin inhibitor
Cysteine 47 of Kunitz-type protease inhibitor 2 and cysteine 121
Cysteine 121 and cysteine 300 of Amyloid-beta precursor protein
Cysteine 121 and cysteine 63 of Tissue factor pathway inhibitor
Cysteine 105 and cysteine 267 of Tissue factor pathway inhibitor
Cysteine 47 of Kunitz-type protease inhibitor 2 and cysteine 105
Cysteine 105 and cysteine 49 of Pancreatic trypsin inhibitor
Cysteine 105 and cysteine 300 of Amyloid-beta precursor protein
Cysteine 105 and cysteine 63 of Tissue factor pathway inhibitor
Cysteine 253 and cysteine 171 of Tissue factor pathway inhibitor
More...Cysteine 277 and cysteine 171 of Tissue factor pathway inhibitor
Cysteine 121 and cysteine 324 of Amyloid-beta precursor protein
Cysteine 253 and cysteine 267 of Tissue factor pathway inhibitor
Intramolecular
Cysteine 196 and cysteine 263
Cysteine 87 and cysteine 217
Cysteine 228 and cysteine 242
Cysteine 105 and cysteine 121
Cysteine 253 and cysteine 277
2r9p B 58 F 14
A redox-regulated disulphide may form between cysteine 121 of Trypsin-3 and cysteine 49 of Pancreatic trypsin inhibitor (58 and 14 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
2r9p
Structure name
human mesotrypsin complexed with bovine pancreatic trypsin inhibitor(bpti)
Structure deposition date
2007-09-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
95
Minimum pKa ?
nan
% buried
nan
Peptide A name
Trypsin-3
Peptide B name
Pancreatic trypsin inhibitor
Peptide A accession
P35030
Peptide B accession
P00974
Peptide A residue number
121
Peptide B residue number
49
Ligandability
Cysteine 121 of Trypsin-3
Cysteine 49 of Pancreatic trypsin inhibitor
4u32 X 14 A 58
A redox-regulated disulphide may form between cysteine 47 of Kunitz-type protease inhibitor 2 and cysteine 121 of Trypsin-3 (14 and 58 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
4u32
Structure name
human mesotrypsin complexed with hai-2 kunitz domain 1
Structure deposition date
2014-07-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
93
Minimum pKa ?
nan
% buried
nan
Peptide A name
Kunitz-type protease inhibitor 2
Peptide B name
Trypsin-3
Peptide A accession
O43291
Peptide B accession
P35030
Peptide A residue number
47
Peptide B residue number
121
Ligandability
Cysteine 47 of Kunitz-type protease inhibitor 2
Cysteine 121 of Trypsin-3
5c67 A 58 E 14
A redox-regulated disulphide may form between cysteine 121 of Trypsin-3 and cysteine 300 of Amyloid-beta precursor protein (58 and 14 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
5c67
Structure name
human mesotrypsin in complex with amyloid precursor protein inhibitor variant appi-m17g/i18f/f34v
Structure deposition date
2015-06-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
96
Minimum pKa ?
nan
% buried
nan
Peptide A name
Trypsin-3
Peptide B name
Amyloid-beta precursor protein
Peptide A accession
P35030
Peptide B accession
P05067
Peptide A residue number
121
Peptide B residue number
300
Ligandability
Cysteine 121 of Trypsin-3
Cysteine 300 of Amyloid-beta precursor protein
6bx8 C 58 D 14
A redox-regulated disulphide may form between cysteine 121 of Trypsin-3 and cysteine 63 of Tissue factor pathway inhibitor (58 and 14 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
6bx8
Structure name
human mesotrypsin (prss3) complexed with tissue factor pathway inhibitor variant (tfpi1-kd1-k15r-i17c-i34c)
Structure deposition date
2017-12-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
96
Minimum pKa ?
nan
% buried
nan
Peptide A name
Trypsin-3
Peptide B name
Tissue factor pathway inhibitor
Peptide A accession
P35030
Peptide B accession
P10646
Peptide A residue number
121
Peptide B residue number
63
Ligandability
Cysteine 121 of Trypsin-3
Cysteine 63 of Tissue factor pathway inhibitor
6bx8 E 42 F 17
A redox-regulated disulphide may form between cysteine 105 of Trypsin-3 and cysteine 267 of Tissue factor pathway inhibitor (42 and 17 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
6bx8
Structure name
human mesotrypsin (prss3) complexed with tissue factor pathway inhibitor variant (tfpi1-kd1-k15r-i17c-i34c)
Structure deposition date
2017-12-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
96
Minimum pKa ?
nan
% buried
nan
Peptide A name
Trypsin-3
Peptide B name
Tissue factor pathway inhibitor
Peptide A accession
P35030
Peptide B accession
P10646
Peptide A residue number
105
Peptide B residue number
267
Ligandability
Cysteine 105 of Trypsin-3
Cysteine 267 of Tissue factor pathway inhibitor
4u32 X 14 A 42
A redox-regulated disulphide may form between cysteine 47 of Kunitz-type protease inhibitor 2 and cysteine 105 of Trypsin-3 (14 and 42 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
4u32
Structure name
human mesotrypsin complexed with hai-2 kunitz domain 1
Structure deposition date
2014-07-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
96
Minimum pKa ?
nan
% buried
nan
Peptide A name
Kunitz-type protease inhibitor 2
Peptide B name
Trypsin-3
Peptide A accession
O43291
Peptide B accession
P35030
Peptide A residue number
47
Peptide B residue number
105
Ligandability
Cysteine 47 of Kunitz-type protease inhibitor 2
Cysteine 105 of Trypsin-3
2r9p A 42 E 14
A redox-regulated disulphide may form between cysteine 105 of Trypsin-3 and cysteine 49 of Pancreatic trypsin inhibitor (42 and 14 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
2r9p
Structure name
human mesotrypsin complexed with bovine pancreatic trypsin inhibitor(bpti)
Structure deposition date
2007-09-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
94
Minimum pKa ?
nan
% buried
nan
Peptide A name
Trypsin-3
Peptide B name
Pancreatic trypsin inhibitor
Peptide A accession
P35030
Peptide B accession
P00974
Peptide A residue number
105
Peptide B residue number
49
Ligandability
Cysteine 105 of Trypsin-3
Cysteine 49 of Pancreatic trypsin inhibitor
3l33 A 42 E 14
A redox-regulated disulphide may form between cysteine 105 of Trypsin-3 and cysteine 300 of Amyloid-beta precursor protein (42 and 14 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
3l33
Structure name
human mesotrypsin complexed with amyloid precursor protein inhibitor(appi)
Structure deposition date
2009-12-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
95
Minimum pKa ?
nan
% buried
nan
Peptide A name
Trypsin-3
Peptide B name
Amyloid-beta precursor protein
Peptide A accession
P35030
Peptide B accession
P05067
Peptide A residue number
105
Peptide B residue number
300
Ligandability
Cysteine 105 of Trypsin-3
Cysteine 300 of Amyloid-beta precursor protein
6bx8 A 42 B 14
A redox-regulated disulphide may form between cysteine 105 of Trypsin-3 and cysteine 63 of Tissue factor pathway inhibitor (42 and 14 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
6bx8
Structure name
human mesotrypsin (prss3) complexed with tissue factor pathway inhibitor variant (tfpi1-kd1-k15r-i17c-i34c)
Structure deposition date
2017-12-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
98
Minimum pKa ?
nan
% buried
nan
Peptide A name
Trypsin-3
Peptide B name
Tissue factor pathway inhibitor
Peptide A accession
P35030
Peptide B accession
P10646
Peptide A residue number
105
Peptide B residue number
63
Ligandability
Cysteine 105 of Trypsin-3
Cysteine 63 of Tissue factor pathway inhibitor
6bx8 C 191 D 34
A redox-regulated disulphide may form between cysteine 253 of Trypsin-3 and cysteine 171 of Tissue factor pathway inhibitor (191 and 34 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
6bx8
Structure name
human mesotrypsin (prss3) complexed with tissue factor pathway inhibitor variant (tfpi1-kd1-k15r-i17c-i34c)
Structure deposition date
2017-12-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
100
Minimum pKa ?
nan
% buried
nan
Peptide A name
Trypsin-3
Peptide B name
Tissue factor pathway inhibitor
Peptide A accession
P35030
Peptide B accession
P10646
Peptide A residue number
253
Peptide B residue number
171
Ligandability
Cysteine 253 of Trypsin-3
Cysteine 171 of Tissue factor pathway inhibitor
Uncertain whether structure cysteine 34 has been assigned to correct residue.
6bx8 G 220 H 34
A redox-regulated disulphide may form between cysteine 277 of Trypsin-3 and cysteine 171 of Tissue factor pathway inhibitor (220 and 34 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
6bx8
Structure name
human mesotrypsin (prss3) complexed with tissue factor pathway inhibitor variant (tfpi1-kd1-k15r-i17c-i34c)
Structure deposition date
2017-12-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide A name
Trypsin-3
Peptide B name
Tissue factor pathway inhibitor
Peptide A accession
P35030
Peptide B accession
P10646
Peptide A residue number
277
Peptide B residue number
171
Ligandability
Cysteine 277 of Trypsin-3
Cysteine 171 of Tissue factor pathway inhibitor
Uncertain whether structure cysteine 34 has been assigned to correct residue.
3l33 D 58 H 38
A redox-regulated disulphide may form between cysteine 121 of Trypsin-3 and cysteine 324 of Amyloid-beta precursor protein (58 and 38 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
3l33
Structure name
human mesotrypsin complexed with amyloid precursor protein inhibitor(appi)
Structure deposition date
2009-12-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide A name
Trypsin-3
Peptide B name
Amyloid-beta precursor protein
Peptide A accession
P35030
Peptide B accession
P05067
Peptide A residue number
121
Peptide B residue number
324
Ligandability
Cysteine 121 of Trypsin-3
Cysteine 324 of Amyloid-beta precursor protein
6bx8 G 191 H 17
A redox-regulated disulphide may form between cysteine 253 of Trypsin-3 and cysteine 267 of Tissue factor pathway inhibitor (191 and 17 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
28
PDB code
6bx8
Structure name
human mesotrypsin (prss3) complexed with tissue factor pathway inhibitor variant (tfpi1-kd1-k15r-i17c-i34c)
Structure deposition date
2017-12-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
103
Minimum pKa ?
nan
% buried
nan
Peptide A name
Trypsin-3
Peptide B name
Tissue factor pathway inhibitor
Peptide A accession
P35030
Peptide B accession
P10646
Peptide A residue number
253
Peptide B residue number
267
Ligandability
Cysteine 253 of Trypsin-3
Cysteine 267 of Tissue factor pathway inhibitor
3l33 B 136 B 201
A redox-regulated disulphide may form within Trypsin-3 between cysteines 196 and 263 (136 and 201 respectively in this structure).
Details
Redox score ?
86
PDB code
3l33
Structure name
human mesotrypsin complexed with amyloid precursor protein inhibitor(appi)
Structure deposition date
2009-12-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35030
Residue number A
196
Residue number B
263
Peptide name
Trypsin-3
Ligandability
Cysteine 196 of Trypsin-3
Cysteine 263 of Trypsin-3
1h4w A 22 A 157
A redox-regulated disulphide may form within Trypsin-3 between cysteines 87 and 217 (22 and 157 respectively in this structure).
Details
Redox score ?
83
PDB code
1h4w
Structure name
structure of human trypsin iv (brain trypsin)
Structure deposition date
2001-05-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35030
Residue number A
87
Residue number B
217
Peptide name
Trypsin-3
Ligandability
Cysteine 87 of Trypsin-3
Cysteine 217 of Trypsin-3
4u30 D 168 D 182
A redox-regulated disulphide may form within Trypsin-3 between cysteines 228 and 242 (168 and 182 respectively in this structure).
Details
Redox score ?
81
PDB code
4u30
Structure name
human mesotrypsin complexed with bikunin kunitz domain 2
Structure deposition date
2014-07-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35030
Residue number A
228
Residue number B
242
Peptide name
Trypsin-3
Ligandability
Cysteine 228 of Trypsin-3
Cysteine 242 of Trypsin-3
4u30 D 42 D 58
A redox-regulated disulphide may form within Trypsin-3 between cysteines 105 and 121 (42 and 58 respectively in this structure).
Details
Redox score ?
79
PDB code
4u30
Structure name
human mesotrypsin complexed with bikunin kunitz domain 2
Structure deposition date
2014-07-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
101
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35030
Residue number A
105
Residue number B
121
Peptide name
Trypsin-3
Ligandability
Cysteine 105 of Trypsin-3
Cysteine 121 of Trypsin-3
4u32 A 191 A 220
A redox-regulated disulphide may form within Trypsin-3 between cysteines 253 and 277 (191 and 220 respectively in this structure).
Details
Redox score ?
76
PDB code
4u32
Structure name
human mesotrypsin complexed with hai-2 kunitz domain 1
Structure deposition date
2014-07-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
104
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35030
Residue number A
253
Residue number B
277
Peptide name
Trypsin-3
Ligandability
Cysteine 253 of Trypsin-3
Cysteine 277 of Trypsin-3
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