ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Carbonic anhydrase-related protein

Intramolecular
Cysteine 77 and cysteine 80
Cysteine 80 and cysteine 200
Cysteine 77 and cysteine 200
A redox-regulated disulphide may form within Carbonic anhydrase-related protein between cysteines 77 and 80.

Details

Redox score ?
78
PDB code
2w2j
Structure name
crystal structure of the human carbonic anhydrase related protein viii
Structure deposition date
2008-10-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35219
Residue number A
77
Residue number B
80
Peptide name
Carbonic anhydrase-related protein

Ligandability

Cysteine 77 of Carbonic anhydrase-related protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 80 of Carbonic anhydrase-related protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Carbonic anhydrase-related protein between cysteines 80 and 200. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
2w2j
Structure name
crystal structure of the human carbonic anhydrase related protein viii
Structure deposition date
2008-10-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35219
Residue number A
80
Residue number B
200
Peptide name
Carbonic anhydrase-related protein

Ligandability

Cysteine 80 of Carbonic anhydrase-related protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 200 of Carbonic anhydrase-related protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Carbonic anhydrase-related protein between cysteines 77 and 200. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
2w2j
Structure name
crystal structure of the human carbonic anhydrase related protein viii
Structure deposition date
2008-10-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35219
Residue number A
77
Residue number B
200
Peptide name
Carbonic anhydrase-related protein

Ligandability

Cysteine 77 of Carbonic anhydrase-related protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 200 of Carbonic anhydrase-related protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: