a tool for identifying drug-targetable redox-active disulphides

Catenin alpha-1

Intramolecular

Cysteine 767 and cysteine 772

A redox-regulated disulphide may form within Catenin alpha-1 between cysteines 767 and 772.

Details

Redox score ?

77

PDB code

Structure name

full-length human alpha-catenin crystal structure

Structure deposition date

2012-12-17

Thiol separation (Å)

4

Half-sphere exposure sum ?

52

Minimum pK_a ?

10

% buried

16

Peptide accession

Residue number A

767

Residue number B

772

Peptide name

Catenin alpha-1

Ligandability

Cysteine 767 of Catenin alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 772 of Catenin alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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