ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interleukin-13

Intramolecular
Cysteine 78 and cysteine 104
Cysteine 62 and cysteine 90
A redox-regulated disulphide may form within Interleukin-13 between cysteines 78 and 104 (44 and 70 respectively in this structure).

Details

Redox score ?
86
PDB code
5l6y
Structure name
il13 in complex with tralokinumab
Structure deposition date
2016-06-01
Thiol separation (Å)
3
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide accession
P35225
Residue number A
78
Residue number B
104
Peptide name
Interleukin-13

Ligandability

Cysteine 78 of Interleukin-13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 104 of Interleukin-13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-13 between cysteines 62 and 90 (28 and 56 respectively in this structure).

Details

Redox score ?
85
PDB code
5l6y
Structure name
il13 in complex with tralokinumab
Structure deposition date
2016-06-01
Thiol separation (Å)
3
Half-sphere exposure sum ?
49
Minimum pKa ?
8
% buried
19
Peptide accession
P35225
Residue number A
62
Residue number B
90
Peptide name
Interleukin-13

Ligandability

Cysteine 62 of Interleukin-13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 90 of Interleukin-13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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