ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Tyrosine-protein phosphatase non-receptor type 7

Intramolecular
Cysteine 204 and cysteine 291
Cysteine 291 and cysteine 300
A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 7 between cysteines 204 and 291 (183 and 270 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
3o4s
Structure name
crystal structure of heptp with a closed wpd loop and an ordered e- loop
Structure deposition date
2010-07-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
9
% buried
84
Peptide accession
P35236
Residue number A
204
Residue number B
291
Peptide name
Tyrosine-protein phosphatase non-receptor type 7

Ligandability

Cysteine 204 of Tyrosine-protein phosphatase non-receptor type 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 291 of Tyrosine-protein phosphatase non-receptor type 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 7 between cysteines 291 and 300 (270 and 279 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
2qdc
Structure name
crystal structure of the heptp catalytic domain d236a mutant
Structure deposition date
2007-06-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
87
Minimum pKa ?
9
% buried
100
Peptide accession
P35236
Residue number A
291
Residue number B
300
Peptide name
Tyrosine-protein phosphatase non-receptor type 7

Ligandability

Cysteine 291 of Tyrosine-protein phosphatase non-receptor type 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 300 of Tyrosine-protein phosphatase non-receptor type 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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