ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Replication factor C subunit 1

Intramolecular
Cysteine 750 and cysteine 767 L
Cysteine 750 and cysteine 752 L
Cysteine 752 and cysteine 767 L
A redox-regulated disulphide may form within Replication factor C subunit 1 between cysteines 750 and 767.

Details

Redox score ?
64
PDB code
6vvo
Structure name
structure of the human clamp loader (replication factor c, rfc) bound to the sliding clamp (proliferating cell nuclear antigen, pcna)
Structure deposition date
2020-02-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
80
Minimum pKa ?
9
% buried
98
Peptide accession
P35251
Residue number A
750
Residue number B
767
Peptide name
Replication factor C subunit 1

Ligandability

Cysteine 750 of Replication factor C subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 767 of Replication factor C subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Replication factor C subunit 1 between cysteines 750 and 752. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
6vvo
Structure name
structure of the human clamp loader (replication factor c, rfc) bound to the sliding clamp (proliferating cell nuclear antigen, pcna)
Structure deposition date
2020-02-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
86
Minimum pKa ?
9
% buried
100
Peptide accession
P35251
Residue number A
750
Residue number B
752
Peptide name
Replication factor C subunit 1

Ligandability

Cysteine 750 of Replication factor C subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 752 of Replication factor C subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Replication factor C subunit 1 between cysteines 752 and 767. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
25
PDB code
6vvo
Structure name
structure of the human clamp loader (replication factor c, rfc) bound to the sliding clamp (proliferating cell nuclear antigen, pcna)
Structure deposition date
2020-02-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
14
% buried
98
Peptide accession
P35251
Residue number A
752
Residue number B
767
Peptide name
Replication factor C subunit 1

Ligandability

Cysteine 752 of Replication factor C subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 767 of Replication factor C subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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