ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Mu-type opioid receptor

Intramolecular
Cysteine 142 and cysteine 219
Cysteine 170 and cysteine 251
Cysteine 159 and cysteine 251
Cysteine 79 and cysteine 330
Cysteine 292 and cysteine 330
A redox-regulated disulphide may form within Mu-type opioid receptor between cysteines 142 and 219.

Details

Redox score ?
84
PDB code
8efq
Structure name
damgo-bound mu-opioid receptor-gi complex
Structure deposition date
2022-09-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35372
Residue number A
142
Residue number B
219
Peptide name
Mu-type opioid receptor

Ligandability

Cysteine 142 of Mu-type opioid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 219 of Mu-type opioid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mu-type opioid receptor between cysteines 170 and 251. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
5c1m
Structure name
crystal structure of active mu-opioid receptor bound to the agonist bu72
Structure deposition date
2015-06-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
47
Peptide accession
P42866
Residue number A
170
Residue number B
251
Peptide name
Mu-type opioid receptor

Ligandability

Cysteine 170 of Mu-type opioid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 251 of Mu-type opioid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mu-type opioid receptor between cysteines 159 and 251. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
5c1m
Structure name
crystal structure of active mu-opioid receptor bound to the agonist bu72
Structure deposition date
2015-06-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
74
Peptide accession
P42866
Residue number A
159
Residue number B
251
Peptide name
Mu-type opioid receptor

Ligandability

Cysteine 159 of Mu-type opioid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 251 of Mu-type opioid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mu-type opioid receptor between cysteines 79 and 330. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
5c1m
Structure name
crystal structure of active mu-opioid receptor bound to the agonist bu72
Structure deposition date
2015-06-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
60
Peptide accession
P42866
Residue number A
79
Residue number B
330
Peptide name
Mu-type opioid receptor

Ligandability

Cysteine 79 of Mu-type opioid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 330 of Mu-type opioid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mu-type opioid receptor between cysteines 292 and 330. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
5c1m
Structure name
crystal structure of active mu-opioid receptor bound to the agonist bu72
Structure deposition date
2015-06-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
11
% buried
74
Peptide accession
P42866
Residue number A
292
Residue number B
330
Peptide name
Mu-type opioid receptor

Ligandability

Cysteine 292 of Mu-type opioid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 330 of Mu-type opioid receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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