ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Prostaglandin E2 receptor EP4 subtype

Intramolecular
Cysteine 92 and cysteine 170
Cysteine 111 and cysteine 202
Cysteine 43 and cysteine 59
A redox-regulated disulphide may form within Prostaglandin E2 receptor EP4 subtype between cysteines 92 and 170.

Details

Redox score ?
85
PDB code
7d7m
Structure name
cryo-em structure of the prostaglandin e receptor ep4 coupled to g protein
Structure deposition date
2020-10-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35408
Residue number A
92
Residue number B
170
Peptide name
Prostaglandin E2 receptor EP4 subtype

Ligandability

Cysteine 92 of Prostaglandin E2 receptor EP4 subtype

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 170 of Prostaglandin E2 receptor EP4 subtype

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prostaglandin E2 receptor EP4 subtype between cysteines 111 and 202. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
7d7m
Structure name
cryo-em structure of the prostaglandin e receptor ep4 coupled to g protein
Structure deposition date
2020-10-05
Thiol separation (Å)
6
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
51
Peptide accession
P35408
Residue number A
111
Residue number B
202
Peptide name
Prostaglandin E2 receptor EP4 subtype

Ligandability

Cysteine 111 of Prostaglandin E2 receptor EP4 subtype

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 202 of Prostaglandin E2 receptor EP4 subtype

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prostaglandin E2 receptor EP4 subtype between cysteines 43 and 59. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
7d7m
Structure name
cryo-em structure of the prostaglandin e receptor ep4 coupled to g protein
Structure deposition date
2020-10-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
20
Peptide accession
P35408
Residue number A
43
Residue number B
59
Peptide name
Prostaglandin E2 receptor EP4 subtype

Ligandability

Cysteine 43 of Prostaglandin E2 receptor EP4 subtype

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 59 of Prostaglandin E2 receptor EP4 subtype

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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