a tool for identifying drug-targetable redox-active disulphides

Alpha-L-iduronidase

Intramolecular

Cysteine 541 and cysteine 577

A redox-regulated disulphide may form within Alpha-L-iduronidase between cysteines 541 and 577.

Details

Redox score ?

72

PDB code

Structure name

human iduronidase apo structure p21 form

Structure deposition date

2013-09-03

Thiol separation (Å)

3

Half-sphere exposure sum ?

91

Minimum pK_a ?

9

% buried

100

Peptide accession

Residue number A

541

Residue number B

577

Peptide name

Alpha-L-iduronidase

Ligandability

Cysteine 541 of Alpha-L-iduronidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 577 of Alpha-L-iduronidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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