Sodium channel protein type 4 subunit alpha
Intermolecular
Cysteine 1024 and cysteine 181 of Sodium channel subunit beta-1
Intramolecular
Cysteine 731 and cysteine 737
Cysteine 769 and cysteine 778
Cysteine 1553 and cysteine 1568
Cysteine 1189 and cysteine 1209
Cysteine 369 and cysteine 375
Cysteine 280 and cysteine 360
Cysteine 360 and cysteine 375
Cysteine 280 and cysteine 375
Cysteine 560 and cysteine 561
More...Cysteine 360 and cysteine 369
Cysteine 280 and cysteine 369
Cysteine 1576 and cysteine 1579
Cysteine 729 and cysteine 731
6agf A 1024 B 181
A redox-regulated disulphide may form between cysteine 1024 of Sodium channel protein type 4 subunit alpha and cysteine 181 of Sodium channel subunit beta-1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
6agf
Structure name
structure of the human voltage-gated sodium channel nav1
Structure deposition date
2018-08-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
32
Peptide A name
Sodium channel protein type 4 subunit alpha
Peptide B name
Sodium channel subunit beta-1
Peptide A accession
P35499
Peptide B accession
Q07699
Peptide A residue number
1024
Peptide B residue number
181
Ligandability
Cysteine 1024 of Sodium channel protein type 4 subunit alpha
Cysteine 181 of Sodium channel subunit beta-1
6agf A 731 A 737
A redox-regulated disulphide may form within Sodium channel protein type 4 subunit alpha between cysteines 731 and 737.
Details
Redox score ?
87
PDB code
6agf
Structure name
structure of the human voltage-gated sodium channel nav1
Structure deposition date
2018-08-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
32
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35499
Residue number A
731
Residue number B
737
Peptide name
Sodium channel protein type 4 subunit alpha
Ligandability
Cysteine 731 of Sodium channel protein type 4 subunit alpha
Cysteine 737 of Sodium channel protein type 4 subunit alpha
6agf A 769 A 778
A redox-regulated disulphide may form within Sodium channel protein type 4 subunit alpha between cysteines 769 and 778.
Details
Redox score ?
87
PDB code
6agf
Structure name
structure of the human voltage-gated sodium channel nav1
Structure deposition date
2018-08-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35499
Residue number A
769
Residue number B
778
Peptide name
Sodium channel protein type 4 subunit alpha
Ligandability
Cysteine 769 of Sodium channel protein type 4 subunit alpha
Cysteine 778 of Sodium channel protein type 4 subunit alpha
6agf A 1553 A 1568
A redox-regulated disulphide may form within Sodium channel protein type 4 subunit alpha between cysteines 1553 and 1568.
Details
Redox score ?
85
PDB code
6agf
Structure name
structure of the human voltage-gated sodium channel nav1
Structure deposition date
2018-08-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35499
Residue number A
1553
Residue number B
1568
Peptide name
Sodium channel protein type 4 subunit alpha
Ligandability
Cysteine 1553 of Sodium channel protein type 4 subunit alpha
Cysteine 1568 of Sodium channel protein type 4 subunit alpha
6agf A 1189 A 1209
A redox-regulated disulphide may form within Sodium channel protein type 4 subunit alpha between cysteines 1189 and 1209.
Details
Redox score ?
85
PDB code
6agf
Structure name
structure of the human voltage-gated sodium channel nav1
Structure deposition date
2018-08-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35499
Residue number A
1189
Residue number B
1209
Peptide name
Sodium channel protein type 4 subunit alpha
Ligandability
Cysteine 1189 of Sodium channel protein type 4 subunit alpha
Cysteine 1209 of Sodium channel protein type 4 subunit alpha
6agf A 369 A 375
A redox-regulated disulphide may form within Sodium channel protein type 4 subunit alpha between cysteines 369 and 375.
Details
Redox score ?
84
PDB code
6agf
Structure name
structure of the human voltage-gated sodium channel nav1
Structure deposition date
2018-08-11
Thiol separation (Å)
3
Half-sphere exposure sum ?
70
Minimum pKa ?
7
% buried
66
Peptide accession
P35499
Residue number A
369
Residue number B
375
Peptide name
Sodium channel protein type 4 subunit alpha
Ligandability
Cysteine 369 of Sodium channel protein type 4 subunit alpha
Cysteine 375 of Sodium channel protein type 4 subunit alpha
6agf A 280 A 360
A redox-regulated disulphide may form within Sodium channel protein type 4 subunit alpha between cysteines 280 and 360.
Details
Redox score ?
79
PDB code
6agf
Structure name
structure of the human voltage-gated sodium channel nav1
Structure deposition date
2018-08-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35499
Residue number A
280
Residue number B
360
Peptide name
Sodium channel protein type 4 subunit alpha
Ligandability
Cysteine 280 of Sodium channel protein type 4 subunit alpha
Cysteine 360 of Sodium channel protein type 4 subunit alpha
6agf A 360 A 375
A redox-regulated disulphide may form within Sodium channel protein type 4 subunit alpha between cysteines 360 and 375.
Details
Redox score ?
73
PDB code
6agf
Structure name
structure of the human voltage-gated sodium channel nav1
Structure deposition date
2018-08-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
7
% buried
nan
Peptide accession
P35499
Residue number A
360
Residue number B
375
Peptide name
Sodium channel protein type 4 subunit alpha
Ligandability
Cysteine 360 of Sodium channel protein type 4 subunit alpha
Cysteine 375 of Sodium channel protein type 4 subunit alpha
6agf A 280 A 375
A redox-regulated disulphide may form within Sodium channel protein type 4 subunit alpha between cysteines 280 and 375.
Details
Redox score ?
67
PDB code
6agf
Structure name
structure of the human voltage-gated sodium channel nav1
Structure deposition date
2018-08-11
Thiol separation (Å)
6
Half-sphere exposure sum ?
72
Minimum pKa ?
7
% buried
nan
Peptide accession
P35499
Residue number A
280
Residue number B
375
Peptide name
Sodium channel protein type 4 subunit alpha
Ligandability
Cysteine 280 of Sodium channel protein type 4 subunit alpha
Cysteine 375 of Sodium channel protein type 4 subunit alpha
6agf A 560 A 561
A redox-regulated disulphide may form within Sodium channel protein type 4 subunit alpha between cysteines 560 and 561. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
6agf
Structure name
structure of the human voltage-gated sodium channel nav1
Structure deposition date
2018-08-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
18
Minimum pKa ?
9
% buried
0
Peptide accession
P35499
Residue number A
560
Residue number B
561
Peptide name
Sodium channel protein type 4 subunit alpha
Ligandability
Cysteine 560 of Sodium channel protein type 4 subunit alpha
Cysteine 561 of Sodium channel protein type 4 subunit alpha
6agf A 360 A 369
A redox-regulated disulphide may form within Sodium channel protein type 4 subunit alpha between cysteines 360 and 369. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
6agf
Structure name
structure of the human voltage-gated sodium channel nav1
Structure deposition date
2018-08-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
15
% buried
nan
Peptide accession
P35499
Residue number A
360
Residue number B
369
Peptide name
Sodium channel protein type 4 subunit alpha
Ligandability
Cysteine 360 of Sodium channel protein type 4 subunit alpha
Cysteine 369 of Sodium channel protein type 4 subunit alpha
6agf A 280 A 369
A redox-regulated disulphide may form within Sodium channel protein type 4 subunit alpha between cysteines 280 and 369. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
6agf
Structure name
structure of the human voltage-gated sodium channel nav1
Structure deposition date
2018-08-11
Thiol separation (Å)
5
Half-sphere exposure sum ?
73
Minimum pKa ?
15
% buried
nan
Peptide accession
P35499
Residue number A
280
Residue number B
369
Peptide name
Sodium channel protein type 4 subunit alpha
Ligandability
Cysteine 280 of Sodium channel protein type 4 subunit alpha
Cysteine 369 of Sodium channel protein type 4 subunit alpha
6agf A 1576 A 1579
A redox-regulated disulphide may form within Sodium channel protein type 4 subunit alpha between cysteines 1576 and 1579. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6agf
Structure name
structure of the human voltage-gated sodium channel nav1
Structure deposition date
2018-08-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
46
Minimum pKa ?
10
% buried
52
Peptide accession
P35499
Residue number A
1576
Residue number B
1579
Peptide name
Sodium channel protein type 4 subunit alpha
Ligandability
Cysteine 1576 of Sodium channel protein type 4 subunit alpha
Cysteine 1579 of Sodium channel protein type 4 subunit alpha
6agf A 729 A 731
A redox-regulated disulphide may form within Sodium channel protein type 4 subunit alpha between cysteines 729 and 731. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
6agf
Structure name
structure of the human voltage-gated sodium channel nav1
Structure deposition date
2018-08-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
44
Minimum pKa ?
9
% buried
nan
Peptide accession
P35499
Residue number A
729
Residue number B
731
Peptide name
Sodium channel protein type 4 subunit alpha
Ligandability
Cysteine 729 of Sodium channel protein type 4 subunit alpha
Cysteine 731 of Sodium channel protein type 4 subunit alpha
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