ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Chloride channel protein 1

Intramolecular
Cysteine 819 and cysteine 820
Cysteine 357 and cysteine 358
Cysteine 277 and cysteine 278
Cysteine 179 and cysteine 481
Cysteine 242 and cysteine 277
Cysteine 271 and cysteine 278
A redox-regulated disulphide may form within Chloride channel protein 1 between cysteines 819 and 820. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
6qvd
Structure name
cryoem structure of the human clc-1 chloride channel, cbs state 2
Structure deposition date
2019-03-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
25
Minimum pKa ?
9
% buried
0
Peptide accession
P35523
Residue number A
819
Residue number B
820
Peptide name
Chloride channel protein 1

Ligandability

Cysteine 819 of Chloride channel protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 820 of Chloride channel protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Chloride channel protein 1 between cysteines 357 and 358. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
6qv6
Structure name
cryoem structure of the human clc-1 chloride channel, membrane domain
Structure deposition date
2019-03-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
74
Minimum pKa ?
10
% buried
60
Peptide accession
P35523
Residue number A
357
Residue number B
358
Peptide name
Chloride channel protein 1

Ligandability

Cysteine 357 of Chloride channel protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 358 of Chloride channel protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Chloride channel protein 1 between cysteines 277 and 278. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
6qvb
Structure name
cryoem structure of the human clc-1 chloride channel, cbs state 3
Structure deposition date
2019-03-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
90
Minimum pKa ?
12
% buried
100
Peptide accession
P35523
Residue number A
277
Residue number B
278
Peptide name
Chloride channel protein 1

Ligandability

Cysteine 277 of Chloride channel protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 278 of Chloride channel protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Chloride channel protein 1 between cysteines 179 and 481. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
6qvb
Structure name
cryoem structure of the human clc-1 chloride channel, cbs state 3
Structure deposition date
2019-03-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
80
Minimum pKa ?
11
% buried
86
Peptide accession
P35523
Residue number A
179
Residue number B
481
Peptide name
Chloride channel protein 1

Ligandability

Cysteine 179 of Chloride channel protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 481 of Chloride channel protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Chloride channel protein 1 between cysteines 242 and 277. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
6qvb
Structure name
cryoem structure of the human clc-1 chloride channel, cbs state 3
Structure deposition date
2019-03-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
85
Minimum pKa ?
11
% buried
84
Peptide accession
P35523
Residue number A
242
Residue number B
277
Peptide name
Chloride channel protein 1

Ligandability

Cysteine 242 of Chloride channel protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 277 of Chloride channel protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Chloride channel protein 1 between cysteines 271 and 278. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
21
PDB code
6qvb
Structure name
cryoem structure of the human clc-1 chloride channel, cbs state 3
Structure deposition date
2019-03-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
100
Minimum pKa ?
12
% buried
100
Peptide accession
P35523
Residue number A
271
Residue number B
278
Peptide name
Chloride channel protein 1

Ligandability

Cysteine 271 of Chloride channel protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 278 of Chloride channel protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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