ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Coatomer subunit beta'

Intramolecular
Cysteine 190 and cysteine 234
Cysteine 234 and cysteine 276
Cysteine 351 and cysteine 370
A redox-regulated disulphide may form within Coatomer subunit beta' between cysteines 190 and 234. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
8d41
Structure name
crystal structure of the human copb2 wd-domain in complex with oicr- 6254
Structure deposition date
2022-06-01
Thiol separation (Å)
6
Half-sphere exposure sum ?
98
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35606
Residue number A
190
Residue number B
234
Peptide name
Coatomer subunit beta'

Ligandability

Cysteine 190 of Coatomer subunit beta'

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 234 of Coatomer subunit beta'

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Coatomer subunit beta' between cysteines 234 and 276. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
8d41
Structure name
crystal structure of the human copb2 wd-domain in complex with oicr- 6254
Structure deposition date
2022-06-01
Thiol separation (Å)
6
Half-sphere exposure sum ?
101
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35606
Residue number A
234
Residue number B
276
Peptide name
Coatomer subunit beta'

Ligandability

Cysteine 234 of Coatomer subunit beta'

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 276 of Coatomer subunit beta'

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Coatomer subunit beta' between cysteines 351 and 370. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
8d30
Structure name
crystal structure of the human copb2 wd-domains
Structure deposition date
2022-05-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
9
% buried
46
Peptide accession
P35606
Residue number A
351
Residue number B
370
Peptide name
Coatomer subunit beta'

Ligandability

Cysteine 351 of Coatomer subunit beta'

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 370 of Coatomer subunit beta'

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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