ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Alpha-actinin-2

Intermolecular
Cysteine 270 and cysteine 862
Intramolecular
Cysteine 483 and cysteine 487
A redox-regulated disulphide may form between two units of Alpha-actinin-2 at cysteines 270 and 862. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7ank
Structure name
crystal structure of sarcomeric protein fatz-1 (d91-fatz-1 construct) in complex with half dimer of alpha-actinin-2
Structure deposition date
2020-10-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
44
Peptide A name
Alpha-actinin-2
Peptide B name
Alpha-actinin-2
Peptide A accession
P35609
Peptide B accession
P35609
Peptide A residue number
270
Peptide B residue number
862

Ligandability

Cysteine 270 of Alpha-actinin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 862 of Alpha-actinin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Alpha-actinin-2 between cysteines 483 and 487 (96 and 100 respectively in this structure).

Details

Redox score ?
72
PDB code
1quu
Structure name
crystal structure of two central spectrin-like repeats from alpha- actinin
Structure deposition date
1999-07-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
39
Peptide accession
P35609
Residue number A
483
Residue number B
487
Peptide name
Alpha-actinin-2

Ligandability

Cysteine 483 of Alpha-actinin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 487 of Alpha-actinin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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