ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Basigin

Intramolecular
Cysteine 157 and cysteine 203
Cysteine 242 and cysteine 301
Cysteine 44 and cysteine 108
A redox-regulated disulphide may form within Basigin between cysteines 157 and 203 (41 and 87 respectively in this structure).

Details

Redox score ?
82
PDB code
5x0t
Structure name
crystal structure of cd147 c2 domain in complex with fab of its monoclonal antibody 6h8
Structure deposition date
2017-01-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35613
Residue number A
157
Residue number B
203
Peptide name
Basigin

Ligandability

Cysteine 157 of Basigin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 203 of Basigin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Basigin between cysteines 242 and 301 (126 and 185 respectively in this structure).

Details

Redox score ?
82
PDB code
4u0q
Structure name
plasmodium falciparum reticulocyte-binding protein homologue 5 (pfrh5) bound to basigin
Structure deposition date
2014-07-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35613
Residue number A
242
Residue number B
301
Peptide name
Basigin

Ligandability

Cysteine 242 of Basigin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 301 of Basigin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Basigin between cysteines 44 and 108 (23 and 87 respectively in this structure).

Details

Redox score ?
79
PDB code
3qr2
Structure name
wild type cd147 ig0 domain
Structure deposition date
2011-02-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
93
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35613
Residue number A
44
Residue number B
108
Peptide name
Basigin

Ligandability

Cysteine 44 of Basigin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 108 of Basigin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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