ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

RNA-binding protein FUS

Intramolecular
Cysteine 433 and cysteine 444
Cysteine 444 and cysteine 447
Cysteine 433 and cysteine 447
Cysteine 428 and cysteine 444
Cysteine 428 and cysteine 433
Cysteine 428 and cysteine 447
A redox-regulated disulphide may form within RNA-binding protein FUS between cysteines 433 and 444.

Details

Redox score ?
89
PDB code
6g99
Structure name
solution structure of fus-znf bound to uggug
Structure deposition date
2018-04-10
Thiol separation (Å)
3
Half-sphere exposure sum ?
45
Minimum pKa ?
8
% buried
6
Peptide accession
P35637
Residue number A
433
Residue number B
444
Peptide name
RNA-binding protein FUS

Ligandability

Cysteine 433 of RNA-binding protein FUS

Cysteine 444 of RNA-binding protein FUS

A redox-regulated disulphide may form within RNA-binding protein FUS between cysteines 444 and 447.

Details

Redox score ?
86
PDB code
6g99
Structure name
solution structure of fus-znf bound to uggug
Structure deposition date
2018-04-10
Thiol separation (Å)
3
Half-sphere exposure sum ?
47
Minimum pKa ?
8
% buried
5
Peptide accession
P35637
Residue number A
444
Residue number B
447
Peptide name
RNA-binding protein FUS

Ligandability

Cysteine 444 of RNA-binding protein FUS

Cysteine 447 of RNA-binding protein FUS

A redox-regulated disulphide may form within RNA-binding protein FUS between cysteines 433 and 447.

Details

Redox score ?
85
PDB code
6g99
Structure name
solution structure of fus-znf bound to uggug
Structure deposition date
2018-04-10
Thiol separation (Å)
3
Half-sphere exposure sum ?
38
Minimum pKa ?
8
% buried
0
Peptide accession
P35637
Residue number A
433
Residue number B
447
Peptide name
RNA-binding protein FUS

Ligandability

Cysteine 433 of RNA-binding protein FUS

Cysteine 447 of RNA-binding protein FUS

A redox-regulated disulphide may form within RNA-binding protein FUS between cysteines 428 and 444.

Details

Redox score ?
84
PDB code
6g99
Structure name
solution structure of fus-znf bound to uggug
Structure deposition date
2018-04-10
Thiol separation (Å)
3
Half-sphere exposure sum ?
54
Minimum pKa ?
8
% buried
nan
Peptide accession
P35637
Residue number A
428
Residue number B
444
Peptide name
RNA-binding protein FUS

Ligandability

Cysteine 428 of RNA-binding protein FUS

Cysteine 444 of RNA-binding protein FUS

A redox-regulated disulphide may form within RNA-binding protein FUS between cysteines 428 and 433.

Details

Redox score ?
83
PDB code
6g99
Structure name
solution structure of fus-znf bound to uggug
Structure deposition date
2018-04-10
Thiol separation (Å)
3
Half-sphere exposure sum ?
45
Minimum pKa ?
8
% buried
nan
Peptide accession
P35637
Residue number A
428
Residue number B
433
Peptide name
RNA-binding protein FUS

Ligandability

Cysteine 428 of RNA-binding protein FUS

Cysteine 433 of RNA-binding protein FUS

A redox-regulated disulphide may form within RNA-binding protein FUS between cysteines 428 and 447.

Details

Redox score ?
82
PDB code
6g99
Structure name
solution structure of fus-znf bound to uggug
Structure deposition date
2018-04-10
Thiol separation (Å)
3
Half-sphere exposure sum ?
47
Minimum pKa ?
8
% buried
nan
Peptide accession
P35637
Residue number A
428
Residue number B
447
Peptide name
RNA-binding protein FUS

Ligandability

Cysteine 428 of RNA-binding protein FUS

Cysteine 447 of RNA-binding protein FUS

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