ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Glutaredoxin-1

Intramolecular
Cysteine 23 and cysteine 26 L
Cysteine 23 and cysteine 83 L
Cysteine 26 and cysteine 83 L
A redox-regulated disulphide may form within Glutaredoxin-1 between cysteines 23 and 26.

Details

Redox score ?
81
PDB code
1jhb
Structure name
human glutaredoxin in fully reduced form, nmr, 20 structures
Structure deposition date
1998-02-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
8
% buried
28
Peptide accession
P35754
Residue number A
23
Residue number B
26
Peptide name
Glutaredoxin-1

Ligandability

Cysteine 23 of Glutaredoxin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 26 of Glutaredoxin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glutaredoxin-1 between cysteines 23 and 83 (22 and 82 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
4rqr
Structure name
crystal structure of human glutaredoxin with mesna
Structure deposition date
2014-11-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35754
Residue number A
23
Residue number B
83
Peptide name
Glutaredoxin-1

Ligandability

Cysteine 23 of Glutaredoxin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 83 of Glutaredoxin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glutaredoxin-1 between cysteines 26 and 83 (25 and 82 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
4rqr
Structure name
crystal structure of human glutaredoxin with mesna
Structure deposition date
2014-11-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35754
Residue number A
26
Residue number B
83
Peptide name
Glutaredoxin-1

Ligandability

Cysteine 26 of Glutaredoxin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 83 of Glutaredoxin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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