Protein phosphatase 1A
Intermolecular
Cysteine 72 and cysteine 72
Intramolecular
Cysteine 152 and cysteine 251
Cysteine 71 and cysteine 72
Cysteine 152 and cysteine 290
Cysteine 268 and cysteine 290
Cysteine 71 and cysteine 144
Cysteine 238 and cysteine 275
6b67 A 72 B 72
A redox-regulated disulphide may form between two units of Protein phosphatase 1A at cysteines 72 and 72. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
6b67
Structure name
human pp2calpha (ppm1a) complexed with cyclic peptide c(mpsipyva)
Structure deposition date
2017-10-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
12
% buried
93
Peptide A name
Protein phosphatase 1A
Peptide B name
Protein phosphatase 1A
Peptide A accession
P35813
Peptide B accession
P35813
Peptide A residue number
72
Peptide B residue number
72
Ligandability
4rag A 152 A 251
A redox-regulated disulphide may form within Protein phosphatase 1A between cysteines 152 and 251.
Details
Redox score ?
76
PDB code
4rag
Structure name
crystal structure of ppc2a-d38k
Structure deposition date
2014-09-10
Thiol separation (Å)
3
Half-sphere exposure sum ?
77
Minimum pKa ?
8
% buried
68
Peptide accession
P35813
Residue number A
152
Residue number B
251
Peptide name
Protein phosphatase 1A
Ligandability
Cysteine 152 of Protein phosphatase 1A
Cysteine 251 of Protein phosphatase 1A
3fxo A 71 A 72
A redox-regulated disulphide may form within Protein phosphatase 1A between cysteines 71 and 72. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
3fxo
Structure name
crystal structure of human protein phosphatase 1a (ppm1a) bound with phosphate at 1 mm of mn2+
Structure deposition date
2009-01-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
76
Peptide accession
P35813
Residue number A
71
Residue number B
72
Peptide name
Protein phosphatase 1A
Ligandability
Cysteine 71 of Protein phosphatase 1A
Cysteine 72 of Protein phosphatase 1A
3fxo A 152 A 290
A redox-regulated disulphide may form within Protein phosphatase 1A between cysteines 152 and 290. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
3fxo
Structure name
crystal structure of human protein phosphatase 1a (ppm1a) bound with phosphate at 1 mm of mn2+
Structure deposition date
2009-01-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
7
% buried
84
Peptide accession
P35813
Residue number A
152
Residue number B
290
Peptide name
Protein phosphatase 1A
Ligandability
Cysteine 152 of Protein phosphatase 1A
Cysteine 290 of Protein phosphatase 1A
6b67 B 268 B 290
A redox-regulated disulphide may form within Protein phosphatase 1A between cysteines 268 and 290. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
6b67
Structure name
human pp2calpha (ppm1a) complexed with cyclic peptide c(mpsipyva)
Structure deposition date
2017-10-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
82
Minimum pKa ?
12
% buried
100
Peptide accession
P35813
Residue number A
268
Residue number B
290
Peptide name
Protein phosphatase 1A
Ligandability
Cysteine 268 of Protein phosphatase 1A
Cysteine 290 of Protein phosphatase 1A
4raf A 71 A 144
A redox-regulated disulphide may form within Protein phosphatase 1A between cysteines 71 and 144. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
4raf
Structure name
crystal structure of pp2ca-d38a
Structure deposition date
2014-09-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
100
Peptide accession
P35813
Residue number A
71
Residue number B
144
Peptide name
Protein phosphatase 1A
Ligandability
Cysteine 71 of Protein phosphatase 1A
Cysteine 144 of Protein phosphatase 1A
3fxm A 238 A 275
A redox-regulated disulphide may form within Protein phosphatase 1A between cysteines 238 and 275. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
3fxm
Structure name
crystal structure of human protein phosphatase 1a (ppm1a) bound with citrate at 10 mm of mn2+
Structure deposition date
2009-01-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
90
Minimum pKa ?
13
% buried
99
Peptide accession
P35813
Residue number A
238
Residue number B
275
Peptide name
Protein phosphatase 1A
Ligandability
Cysteine 238 of Protein phosphatase 1A
Cysteine 275 of Protein phosphatase 1A
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