ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Intramolecular
Cysteine 84 and cysteine 92
Cysteine 511 and cysteine 519
Cysteine 36 and cysteine 40
Cysteine 40 and cysteine 44
Cysteine 84 and cysteine 122
Cysteine 44 and cysteine 51
Cysteine 92 and cysteine 122
A redox-regulated disulphide may form within Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta between cysteines 84 and 92.

Details

Redox score ?
73
PDB code
7jsn
Structure name
structure of the visual signaling complex between transducin and phosphodiesterase 6
Structure deposition date
2020-08-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
7
% buried
76
Peptide accession
P23439
Residue number A
84
Residue number B
92
Peptide name
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Ligandability

Cysteine 84 of Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 92 of Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta between cysteines 511 and 519.

Details

Redox score ?
62
PDB code
6mzb
Structure name
cryo-em structure of phosphodiesterase 6
Structure deposition date
2018-11-04
Thiol separation (Å)
5
Half-sphere exposure sum ?
61
Minimum pKa ?
11
% buried
50
Peptide accession
P23439
Residue number A
511
Residue number B
519
Peptide name
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Ligandability

Cysteine 511 of Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 519 of Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta between cysteines 36 and 40. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
6mzb
Structure name
cryo-em structure of phosphodiesterase 6
Structure deposition date
2018-11-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
30
Minimum pKa ?
9
% buried
0
Peptide accession
P23439
Residue number A
36
Residue number B
40
Peptide name
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Ligandability

Cysteine 36 of Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 40 of Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta between cysteines 40 and 44. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6mzb
Structure name
cryo-em structure of phosphodiesterase 6
Structure deposition date
2018-11-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
43
Minimum pKa ?
9
% buried
16
Peptide accession
P23439
Residue number A
40
Residue number B
44
Peptide name
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Ligandability

Cysteine 40 of Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 44 of Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta between cysteines 84 and 122. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
6mzb
Structure name
cryo-em structure of phosphodiesterase 6
Structure deposition date
2018-11-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
nan
Peptide accession
P23439
Residue number A
84
Residue number B
122
Peptide name
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Ligandability

Cysteine 84 of Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 122 of Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta between cysteines 44 and 51. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7jsn
Structure name
structure of the visual signaling complex between transducin and phosphodiesterase 6
Structure deposition date
2020-08-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
32
Peptide accession
P23439
Residue number A
44
Residue number B
51
Peptide name
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Ligandability

Cysteine 44 of Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 51 of Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta between cysteines 92 and 122. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
6mzb
Structure name
cryo-em structure of phosphodiesterase 6
Structure deposition date
2018-11-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
10
% buried
nan
Peptide accession
P23439
Residue number A
92
Residue number B
122
Peptide name
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Ligandability

Cysteine 92 of Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 122 of Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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