ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Vascular endothelial growth factor receptor 3

Intramolecular
Cysteine 466 and cysteine 486
Cysteine 51 and cysteine 111
Cysteine 158 and cysteine 206
Cysteine 445 and cysteine 534
A redox-regulated disulphide may form within Vascular endothelial growth factor receptor 3 between cysteines 466 and 486.

Details

Redox score ?
91
PDB code
4bsj
Structure name
crystal structure of vegfr-3 extracellular domains d4-5
Structure deposition date
2013-06-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
34
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35916
Residue number A
466
Residue number B
486
Peptide name
Vascular endothelial growth factor receptor 3

Ligandability

Cysteine 466 of Vascular endothelial growth factor receptor 3

Cysteine 486 of Vascular endothelial growth factor receptor 3

A redox-regulated disulphide may form within Vascular endothelial growth factor receptor 3 between cysteines 51 and 111.

Details

Redox score ?
82
PDB code
4bsk
Structure name
crystal structure of vegf-c in complex with vegfr-3 domains d1-2
Structure deposition date
2013-06-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35916
Residue number A
51
Residue number B
111
Peptide name
Vascular endothelial growth factor receptor 3

Ligandability

Cysteine 51 of Vascular endothelial growth factor receptor 3

Cysteine 111 of Vascular endothelial growth factor receptor 3

A redox-regulated disulphide may form within Vascular endothelial growth factor receptor 3 between cysteines 158 and 206.

Details

Redox score ?
82
PDB code
4bsk
Structure name
crystal structure of vegf-c in complex with vegfr-3 domains d1-2
Structure deposition date
2013-06-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35916
Residue number A
158
Residue number B
206
Peptide name
Vascular endothelial growth factor receptor 3

Ligandability

Cysteine 158 of Vascular endothelial growth factor receptor 3

Cysteine 206 of Vascular endothelial growth factor receptor 3

A redox-regulated disulphide may form within Vascular endothelial growth factor receptor 3 between cysteines 445 and 534.

Details

Redox score ?
80
PDB code
4bsj
Structure name
crystal structure of vegfr-3 extracellular domains d4-5
Structure deposition date
2013-06-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P35916
Residue number A
445
Residue number B
534
Peptide name
Vascular endothelial growth factor receptor 3

Ligandability

Cysteine 445 of Vascular endothelial growth factor receptor 3

Cysteine 534 of Vascular endothelial growth factor receptor 3

If this tool was useful for finding a disulphide, please cite: