a tool for identifying drug-targetable redox-active disulphides

Lon protease homolog, mitochondrial

Intramolecular

Cysteine 520 and cysteine 637

A redox-regulated disulphide may form within Lon protease homolog, mitochondrial between cysteines 520 and 637.

Details

Redox score ?

72

PDB code

Structure name

p1c-state of wild type human mitochondrial lonp1 protease with bound substrate protein in presence of atp/adp mix

Structure deposition date

2021-02-08

Thiol separation (Å)

3

Half-sphere exposure sum ?

77

Minimum pK_a ?

8

% buried

91

Peptide accession

Residue number A

520

Residue number B

637

Peptide name

Lon protease homolog, mitochondrial

Ligandability

Cysteine 520 of Lon protease homolog, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 637 of Lon protease homolog, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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