Activin receptor type-1B
Intramolecular
Cysteine 36 and cysteine 39
Cysteine 84 and cysteine 95
Cysteine 46 and cysteine 69
Cysteine 34 and cysteine 52
Cysteine 96 and cysteine 101
Cysteine 52 and cysteine 69
Cysteine 39 and cysteine 46
Cysteine 476 and cysteine 77
Cysteine 46 and cysteine 52
Cysteine 52 and cysteine 101
More...Cysteine 476 and cysteine 49
Cysteine 36 and cysteine 69
Cysteine 34 and cysteine 46
Cysteine 36 and cysteine 46
Cysteine 34 and cysteine 69
Cysteine 52 and cysteine 96
Cysteine 34 and cysteine 101
Cysteine 39 and cysteine 69
Cysteine 34 and cysteine 96
Cysteine 476 and cysteine 109
Cysteine 95 and cysteine 96
Cysteine 476 and cysteine 34
Cysteine 36 and cysteine 52
Cysteine 34 and cysteine 36
Cysteine 84 and cysteine 96
Cysteine 34 and cysteine 39
Cysteine 69 and cysteine 101
Cysteine 95 and cysteine 101
Cysteine 69 and cysteine 96
Cysteine 52 and cysteine 95
Cysteine 476 and cysteine 90
Cysteine 46 and cysteine 101
Cysteine 39 and cysteine 52
Cysteine 34 and cysteine 95
Cysteine 46 and cysteine 96
Cysteine 52 and cysteine 84
Cysteine 476 and cysteine 448
Cysteine 400 and cysteine 34
Cysteine 400 and cysteine 90
Cysteine 400 and cysteine 103
7mrz C 1036 C 1039
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 36 and 39 (1036 and 1039 respectively in this structure).
Details
Redox score ?
85
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
36
Residue number B
39
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 36 of Activin receptor type-1B
Cysteine 39 of Activin receptor type-1B
7oly K 84 K 95
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 84 and 95.
Details
Redox score ?
85
PDB code
7oly
Structure name
structure of activin a in complex with an actriib-alk4 fusion reveal insight into activin receptor interactions
Structure deposition date
2021-05-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
84
Residue number B
95
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 84 of Activin receptor type-1B
Cysteine 95 of Activin receptor type-1B
7mrz C 1046 C 1069
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 46 and 69 (1046 and 1069 respectively in this structure).
Details
Redox score ?
83
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
46
Residue number B
69
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 46 of Activin receptor type-1B
Cysteine 69 of Activin receptor type-1B
7oly K 34 K 52
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 34 and 52.
Details
Redox score ?
83
PDB code
7oly
Structure name
structure of activin a in complex with an actriib-alk4 fusion reveal insight into activin receptor interactions
Structure deposition date
2021-05-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
34
Residue number B
52
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 34 of Activin receptor type-1B
Cysteine 52 of Activin receptor type-1B
7mrz C 1096 C 1101
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 96 and 101 (1096 and 1101 respectively in this structure).
Details
Redox score ?
80
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
96
Residue number B
101
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 96 of Activin receptor type-1B
Cysteine 101 of Activin receptor type-1B
7mrz C 1052 C 1069
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 52 and 69 (1052 and 1069 respectively in this structure).
Details
Redox score ?
73
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
52
Residue number B
69
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 52 of Activin receptor type-1B
Cysteine 69 of Activin receptor type-1B
7oly K 39 K 46
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 39 and 46.
Details
Redox score ?
72
PDB code
7oly
Structure name
structure of activin a in complex with an actriib-alk4 fusion reveal insight into activin receptor interactions
Structure deposition date
2021-05-20
Thiol separation (Å)
5
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
39
Residue number B
46
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 39 of Activin receptor type-1B
Cysteine 46 of Activin receptor type-1B
7mrz C 29 C 77
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 476 and 77 (29 and 77 respectively in this structure).
Details
Redox score ?
71
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
476
Residue number B
77
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 476 of Activin receptor type-1B
Cysteine 77 of Activin receptor type-1B
Cysteine 77 in protein B could not be asigned to a Uniprot residue.
7mrz C 1046 C 1052
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 46 and 52 (1046 and 1052 respectively in this structure).
Details
Redox score ?
71
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
46
Residue number B
52
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 46 of Activin receptor type-1B
Cysteine 52 of Activin receptor type-1B
7oly K 52 K 101
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 52 and 101.
Details
Redox score ?
71
PDB code
7oly
Structure name
structure of activin a in complex with an actriib-alk4 fusion reveal insight into activin receptor interactions
Structure deposition date
2021-05-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
52
Residue number B
101
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 52 of Activin receptor type-1B
Cysteine 101 of Activin receptor type-1B
7mrz C 29 C 49
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 476 and 49 (29 and 49 respectively in this structure).
Details
Redox score ?
69
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
5
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
476
Residue number B
49
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 476 of Activin receptor type-1B
Cysteine 49 of Activin receptor type-1B
Cysteine 49 in protein B could not be asigned to a Uniprot residue.
7mrz C 1036 C 1069
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 36 and 69 (1036 and 1069 respectively in this structure).
Details
Redox score ?
69
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
36
Residue number B
69
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 36 of Activin receptor type-1B
Cysteine 69 of Activin receptor type-1B
7mrz C 1034 C 1046
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 34 and 46 (1034 and 1046 respectively in this structure).
Details
Redox score ?
69
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
5
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
34
Residue number B
46
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 34 of Activin receptor type-1B
Cysteine 46 of Activin receptor type-1B
7mrz C 1036 C 1046
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 36 and 46 (1036 and 1046 respectively in this structure).
Details
Redox score ?
68
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
5
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
36
Residue number B
46
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 36 of Activin receptor type-1B
Cysteine 46 of Activin receptor type-1B
7mrz C 1034 C 1069
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 34 and 69 (1034 and 1069 respectively in this structure).
Details
Redox score ?
68
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
5
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
34
Residue number B
69
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 34 of Activin receptor type-1B
Cysteine 69 of Activin receptor type-1B
7oly K 52 K 96
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 52 and 96.
Details
Redox score ?
67
PDB code
7oly
Structure name
structure of activin a in complex with an actriib-alk4 fusion reveal insight into activin receptor interactions
Structure deposition date
2021-05-20
Thiol separation (Å)
5
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
52
Residue number B
96
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 52 of Activin receptor type-1B
Cysteine 96 of Activin receptor type-1B
7mrz C 1034 C 1101
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 34 and 101 (1034 and 1101 respectively in this structure).
Details
Redox score ?
66
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
5
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
34
Residue number B
101
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 34 of Activin receptor type-1B
Cysteine 101 of Activin receptor type-1B
7mrz C 1039 C 1069
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 39 and 69 (1039 and 1069 respectively in this structure).
Details
Redox score ?
61
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
6
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
39
Residue number B
69
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 39 of Activin receptor type-1B
Cysteine 69 of Activin receptor type-1B
7mrz C 1034 C 1096
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 34 and 96 (1034 and 1096 respectively in this structure).
Details
Redox score ?
61
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
5
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
34
Residue number B
96
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 34 of Activin receptor type-1B
Cysteine 96 of Activin receptor type-1B
7mrz C 29 C 109
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 476 and 109 (29 and 109 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
6
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
476
Residue number B
109
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 476 of Activin receptor type-1B
Cysteine 109 of Activin receptor type-1B
Cysteine 109 in protein B could not be asigned to a Uniprot residue.
7mrz C 1095 C 1096
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 95 and 96 (1095 and 1096 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
95
Residue number B
96
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 95 of Activin receptor type-1B
Cysteine 96 of Activin receptor type-1B
7mrz C 29 C 104
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 476 and 34 (29 and 104 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
476
Residue number B
34
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 476 of Activin receptor type-1B
Cysteine 34 of Activin receptor type-1B
Uncertain whether structure cysteine 104 has been assigned to correct residue.
7mrz C 1036 C 1052
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 36 and 52 (1036 and 1052 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
36
Residue number B
52
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 36 of Activin receptor type-1B
Cysteine 52 of Activin receptor type-1B
7mrz C 1034 C 1036
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 34 and 36 (1034 and 1036 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
34
Residue number B
36
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 34 of Activin receptor type-1B
Cysteine 36 of Activin receptor type-1B
7mrz C 1084 C 1096
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 84 and 96 (1084 and 1096 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
84
Residue number B
96
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 84 of Activin receptor type-1B
Cysteine 96 of Activin receptor type-1B
7oly K 34 K 39
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 34 and 39. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7oly
Structure name
structure of activin a in complex with an actriib-alk4 fusion reveal insight into activin receptor interactions
Structure deposition date
2021-05-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
34
Residue number B
39
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 34 of Activin receptor type-1B
Cysteine 39 of Activin receptor type-1B
7mrz C 1069 C 1101
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 69 and 101 (1069 and 1101 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
69
Residue number B
101
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 69 of Activin receptor type-1B
Cysteine 101 of Activin receptor type-1B
7mrz C 1095 C 1101
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 95 and 101 (1095 and 1101 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
95
Residue number B
101
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 95 of Activin receptor type-1B
Cysteine 101 of Activin receptor type-1B
7mrz C 1069 C 1096
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 69 and 96 (1069 and 1096 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
69
Residue number B
96
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 69 of Activin receptor type-1B
Cysteine 96 of Activin receptor type-1B
7oly K 52 K 95
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 52 and 95. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
7oly
Structure name
structure of activin a in complex with an actriib-alk4 fusion reveal insight into activin receptor interactions
Structure deposition date
2021-05-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
52
Residue number B
95
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 52 of Activin receptor type-1B
Cysteine 95 of Activin receptor type-1B
7mrz C 29 C 90
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 476 and 90 (29 and 90 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
476
Residue number B
90
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 476 of Activin receptor type-1B
Cysteine 90 of Activin receptor type-1B
Cysteine 90 in protein B could not be asigned to a Uniprot residue.
7mrz C 1046 C 1101
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 46 and 101 (1046 and 1101 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
46
Residue number B
101
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 46 of Activin receptor type-1B
Cysteine 101 of Activin receptor type-1B
7mrz C 1039 C 1052
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 39 and 52 (1039 and 1052 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
39
Residue number B
52
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 39 of Activin receptor type-1B
Cysteine 52 of Activin receptor type-1B
7mrz C 1034 C 1095
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 34 and 95 (1034 and 1095 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
34
Residue number B
95
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 34 of Activin receptor type-1B
Cysteine 95 of Activin receptor type-1B
7mrz C 1046 C 1096
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 46 and 96 (1046 and 1096 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
46
Residue number B
96
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 46 of Activin receptor type-1B
Cysteine 96 of Activin receptor type-1B
7mrz C 1052 C 1084
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 52 and 84 (1052 and 1084 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
52
Residue number B
84
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 52 of Activin receptor type-1B
Cysteine 84 of Activin receptor type-1B
7mrz C 29 C 59
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 476 and 448 (29 and 59 respectively in this structure).
Details
Redox score ?
nan
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
476
Residue number B
448
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 476 of Activin receptor type-1B
Cysteine 448 of Activin receptor type-1B
Uncertain whether structure cysteine 59 has been assigned to correct residue.
7mrz C 84 C 102
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 400 and 34 (84 and 102 respectively in this structure).
Details
Redox score ?
nan
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
400
Residue number B
34
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 400 of Activin receptor type-1B
Cysteine 34 of Activin receptor type-1B
Uncertain whether structure cysteine 102 has been assigned to correct residue.
7mrz C 84 C 90
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 400 and 90 (84 and 90 respectively in this structure).
Details
Redox score ?
nan
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
400
Residue number B
90
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 400 of Activin receptor type-1B
Cysteine 90 of Activin receptor type-1B
Cysteine 90 in protein B could not be asigned to a Uniprot residue.
7mrz C 84 C 103
A redox-regulated disulphide may form within Activin receptor type-1B between cysteines 400 and 103 (84 and 103 respectively in this structure).
Details
Redox score ?
nan
PDB code
7mrz
Structure name
structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Structure deposition date
2021-05-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36896
Residue number A
400
Residue number B
103
Peptide name
Activin receptor type-1B
Ligandability
Cysteine 400 of Activin receptor type-1B
Cysteine 103 of Activin receptor type-1B
Cysteine 103 in protein B could not be asigned to a Uniprot residue.
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