ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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TGF-beta receptor type-1

Intramolecular
Cysteine 38 and cysteine 41
Cysteine 48 and cysteine 71
Cysteine 86 and cysteine 100
Cysteine 36 and cysteine 54
Cysteine 101 and cysteine 106
Cysteine 36 and cysteine 71
Cysteine 41 and cysteine 48
Cysteine 38 and cysteine 48
Cysteine 54 and cysteine 106
Cysteine 54 and cysteine 101
More...
Cysteine 36 and cysteine 48
Cysteine 36 and cysteine 106
Cysteine 54 and cysteine 71
Cysteine 41 and cysteine 71
Cysteine 38 and cysteine 71
Cysteine 48 and cysteine 54
Cysteine 36 and cysteine 101
Cysteine 415 and cysteine 461
Cysteine 36 and cysteine 38
Cysteine 100 and cysteine 106
Cysteine 86 and cysteine 101
Cysteine 36 and cysteine 41
Cysteine 100 and cysteine 101
Cysteine 71 and cysteine 106
Cysteine 54 and cysteine 100
Cysteine 36 and cysteine 100
Cysteine 347 and cysteine 348
Cysteine 38 and cysteine 54
Cysteine 36 and cysteine 86
Cysteine 86 and cysteine 106
Cysteine 54 and cysteine 86
Cysteine 71 and cysteine 101
Cysteine 348 and cysteine 350
A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 38 and 41 (14 and 17 respectively in this structure).

Details

Redox score ?
87
PDB code
2pjy
Structure name
structural basis for cooperative assembly of the tgf-beta signaling complex
Structure deposition date
2007-04-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
38
Residue number B
41
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 38 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 41 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 48 and 71 (24 and 47 respectively in this structure).

Details

Redox score ?
83
PDB code
6mac
Structure name
ternary structure of gdf11 bound to actriib-ecd and alk5-ecd
Structure deposition date
2018-08-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
48
Residue number B
71
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 48 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 71 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 86 and 100 (62 and 76 respectively in this structure).

Details

Redox score ?
83
PDB code
3kfd
Structure name
ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Structure deposition date
2009-10-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
86
Residue number B
100
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 86 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 36 and 54 (12 and 30 respectively in this structure).

Details

Redox score ?
82
PDB code
3kfd
Structure name
ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Structure deposition date
2009-10-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
36
Residue number B
54
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 36 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 54 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 101 and 106 (77 and 82 respectively in this structure).

Details

Redox score ?
81
PDB code
2pjy
Structure name
structural basis for cooperative assembly of the tgf-beta signaling complex
Structure deposition date
2007-04-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
101
Residue number B
106
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 101 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 106 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 36 and 71 (12 and 47 respectively in this structure).

Details

Redox score ?
72
PDB code
3kfd
Structure name
ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Structure deposition date
2009-10-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
36
Residue number B
71
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 36 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 71 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 41 and 48 (17 and 24 respectively in this structure).

Details

Redox score ?
70
PDB code
3kfd
Structure name
ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Structure deposition date
2009-10-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
41
Residue number B
48
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 41 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 48 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 38 and 48 (14 and 24 respectively in this structure).

Details

Redox score ?
69
PDB code
3kfd
Structure name
ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Structure deposition date
2009-10-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
38
Residue number B
48
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 38 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 48 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 54 and 106 (30 and 82 respectively in this structure).

Details

Redox score ?
67
PDB code
2pjy
Structure name
structural basis for cooperative assembly of the tgf-beta signaling complex
Structure deposition date
2007-04-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
54
Residue number B
106
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 54 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 106 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 54 and 101 (30 and 77 respectively in this structure).

Details

Redox score ?
64
PDB code
3kfd
Structure name
ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Structure deposition date
2009-10-27
Thiol separation (Å)
5
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
54
Residue number B
101
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 54 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 101 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 36 and 48 (12 and 24 respectively in this structure).

Details

Redox score ?
61
PDB code
3kfd
Structure name
ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Structure deposition date
2009-10-27
Thiol separation (Å)
6
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
36
Residue number B
48
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 36 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 48 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 36 and 106 (12 and 82 respectively in this structure).

Details

Redox score ?
61
PDB code
6mac
Structure name
ternary structure of gdf11 bound to actriib-ecd and alk5-ecd
Structure deposition date
2018-08-27
Thiol separation (Å)
6
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
36
Residue number B
106
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 36 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 106 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 54 and 71 (30 and 47 respectively in this structure).

Details

Redox score ?
60
PDB code
2pjy
Structure name
structural basis for cooperative assembly of the tgf-beta signaling complex
Structure deposition date
2007-04-16
Thiol separation (Å)
6
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
54
Residue number B
71
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 54 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 71 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 41 and 71 (17 and 47 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
2pjy
Structure name
structural basis for cooperative assembly of the tgf-beta signaling complex
Structure deposition date
2007-04-16
Thiol separation (Å)
7
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
41
Residue number B
71
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 41 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 71 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 38 and 71 (14 and 47 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
2pjy
Structure name
structural basis for cooperative assembly of the tgf-beta signaling complex
Structure deposition date
2007-04-16
Thiol separation (Å)
6
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
38
Residue number B
71
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 38 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 71 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 48 and 54 (24 and 30 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
3kfd
Structure name
ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Structure deposition date
2009-10-27
Thiol separation (Å)
6
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
48
Residue number B
54
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 48 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 54 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 36 and 101 (12 and 77 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
2pjy
Structure name
structural basis for cooperative assembly of the tgf-beta signaling complex
Structure deposition date
2007-04-16
Thiol separation (Å)
7
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
36
Residue number B
101
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 36 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 101 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 415 and 461. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
3faa
Structure name
crystal structure of tgfbri complexed with a 2-aminoimidazole inhibitor
Structure deposition date
2008-11-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
35
Peptide accession
P36897
Residue number A
415
Residue number B
461
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 415 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 461 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 36 and 38 (12 and 14 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
2pjy
Structure name
structural basis for cooperative assembly of the tgf-beta signaling complex
Structure deposition date
2007-04-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
36
Residue number B
38
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 36 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 38 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 100 and 106 (76 and 82 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
6mac
Structure name
ternary structure of gdf11 bound to actriib-ecd and alk5-ecd
Structure deposition date
2018-08-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
100
Residue number B
106
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 100 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 106 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 86 and 101 (62 and 77 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
6mac
Structure name
ternary structure of gdf11 bound to actriib-ecd and alk5-ecd
Structure deposition date
2018-08-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
86
Residue number B
101
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 86 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 101 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 36 and 41 (12 and 17 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
2pjy
Structure name
structural basis for cooperative assembly of the tgf-beta signaling complex
Structure deposition date
2007-04-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
36
Residue number B
41
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 36 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 41 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 100 and 101 (76 and 77 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
2pjy
Structure name
structural basis for cooperative assembly of the tgf-beta signaling complex
Structure deposition date
2007-04-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
100
Residue number B
101
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 100 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 101 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 71 and 106 (47 and 82 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
6mac
Structure name
ternary structure of gdf11 bound to actriib-ecd and alk5-ecd
Structure deposition date
2018-08-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
71
Residue number B
106
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 71 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 106 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 54 and 100 (30 and 76 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
2pjy
Structure name
structural basis for cooperative assembly of the tgf-beta signaling complex
Structure deposition date
2007-04-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
54
Residue number B
100
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 54 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 36 and 100 (12 and 76 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
3kfd
Structure name
ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Structure deposition date
2009-10-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
36
Residue number B
100
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 36 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 347 and 348. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
5e8x
Structure name
tgf-beta receptor type 1 kinase domain (t204d,i211v,y249f,s280t, y282f,s287n,a350c,l352f) in complex with staurosporine
Structure deposition date
2015-10-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
87
Minimum pKa ?
11
% buried
100
Peptide accession
P36897
Residue number A
347
Residue number B
348
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 347 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 348 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 38 and 54 (14 and 30 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
3kfd
Structure name
ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Structure deposition date
2009-10-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
38
Residue number B
54
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 38 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 54 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 36 and 86 (12 and 62 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
2l5s
Structure name
solution structure of the extracellular domain of the tgf-beta type i receptor
Structure deposition date
2010-11-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
36
Residue number B
86
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 36 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 86 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 86 and 106 (62 and 82 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
2l5s
Structure name
solution structure of the extracellular domain of the tgf-beta type i receptor
Structure deposition date
2010-11-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
86
Residue number B
106
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 86 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 106 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 54 and 86 (30 and 62 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
3kfd
Structure name
ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Structure deposition date
2009-10-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
54
Residue number B
86
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 54 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 86 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 71 and 101 (47 and 77 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
3kfd
Structure name
ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Structure deposition date
2009-10-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36897
Residue number A
71
Residue number B
101
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 71 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 101 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-1 between cysteines 348 and 350.

Details

Redox score ?
nan
PDB code
5e8u
Structure name
tgf-beta receptor type 1 kinase domain (t204d,i211v,y249f,s280t, y282f,s287n,a350c,l352f)
Structure deposition date
2015-10-14
Thiol separation (Å)
7
Half-sphere exposure sum ?
93
Minimum pKa ?
12
% buried
92
Peptide accession
P36897
Residue number A
348
Residue number B
350
Peptide name
TGF-beta receptor type-1

Ligandability

Cysteine 348 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 350 of TGF-beta receptor type-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 350 in protein B could not be asigned to a Uniprot residue.
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