DNA-directed RNA polymerase II subunit RPB9
Intramolecular
Cysteine 86 and cysteine 119
Cysteine 17 and cysteine 42 L
Cysteine 89 and cysteine 119
Cysteine 17 and cysteine 20 L
Cysteine 86 and cysteine 114
Cysteine 89 and cysteine 114
Cysteine 86 and cysteine 89
Cysteine 17 and cysteine 39 L
Cysteine 39 and cysteine 42 L
Cysteine 20 and cysteine 39 L
More...Cysteine 114 and cysteine 119
Cysteine 20 and cysteine 42 L
5iy6 I 86 I 119
A redox-regulated disulphide may form within DNA-directed RNA polymerase II subunit RPB9 between cysteines 86 and 119.
Details
Redox score ?
92
PDB code
5iy6
Structure name
human holo-pic in the closed state
Structure deposition date
2016-03-24
Thiol separation (Å)
3
Half-sphere exposure sum ?
53
Minimum pKa ?
6
% buried
10
Peptide accession
P36954
Residue number A
86
Residue number B
119
Peptide name
DNA-directed RNA polymerase II subunit RPB9
Ligandability
Cysteine 86 of DNA-directed RNA polymerase II subunit RPB9
Cysteine 119 of DNA-directed RNA polymerase II subunit RPB9
7opd I 17 I 42
A redox-regulated disulphide may form within DNA-directed RNA polymerase II subunit RPB9 between cysteines 17 and 42.
Details
Redox score ?
92
PDB code
7opd
Structure name
pol ii-csb-crl4csa-uvssa-spt6-paf (structure 5)
Structure deposition date
2021-05-31
Thiol separation (Å)
3
Half-sphere exposure sum ?
44
Minimum pKa ?
6
% buried
4
Peptide accession
P60899
Residue number A
17
Residue number B
42
Peptide name
DNA-directed RNA polymerase II subunit RPB9
Ligandability
Cysteine 17 of DNA-directed RNA polymerase II subunit RPB9
Cysteine 42 of DNA-directed RNA polymerase II subunit RPB9
7oo3 I 89 I 119
A redox-regulated disulphide may form within DNA-directed RNA polymerase II subunit RPB9 between cysteines 89 and 119.
Details
Redox score ?
89
PDB code
7oo3
Structure name
pol ii-csb-csa-ddb1-uvssa (structure1)
Structure deposition date
2021-05-26
Thiol separation (Å)
3
Half-sphere exposure sum ?
39
Minimum pKa ?
6
% buried
0
Peptide accession
P60899
Residue number A
89
Residue number B
119
Peptide name
DNA-directed RNA polymerase II subunit RPB9
Ligandability
Cysteine 89 of DNA-directed RNA polymerase II subunit RPB9
Cysteine 119 of DNA-directed RNA polymerase II subunit RPB9
7b7u I 17 I 20
A redox-regulated disulphide may form within DNA-directed RNA polymerase II subunit RPB9 between cysteines 17 and 20.
Details
Redox score ?
89
PDB code
7b7u
Structure name
cryo-em structure of mammalian rna polymerase ii in complex with human rpap2
Structure deposition date
2020-12-11
Thiol separation (Å)
3
Half-sphere exposure sum ?
46
Minimum pKa ?
8
% buried
14
Peptide accession
P60899
Residue number A
17
Residue number B
20
Peptide name
DNA-directed RNA polymerase II subunit RPB9
Ligandability
Cysteine 17 of DNA-directed RNA polymerase II subunit RPB9
Cysteine 20 of DNA-directed RNA polymerase II subunit RPB9
5oik I 86 I 114
A redox-regulated disulphide may form within DNA-directed RNA polymerase II subunit RPB9 between cysteines 86 and 114.
Details
Redox score ?
87
PDB code
5oik
Structure name
structure of an rna polymerase ii-dsif transcription elongation complex
Structure deposition date
2017-07-18
Thiol separation (Å)
3
Half-sphere exposure sum ?
64
Minimum pKa ?
5
% buried
14
Peptide accession
Q32P73
Residue number A
86
Residue number B
114
Peptide name
DNA-directed RNA polymerase II subunit RPB9
Ligandability
Cysteine 86 of DNA-directed RNA polymerase II subunit RPB9
Cysteine 114 of DNA-directed RNA polymerase II subunit RPB9
7oob I 89 I 114
A redox-regulated disulphide may form within DNA-directed RNA polymerase II subunit RPB9 between cysteines 89 and 114.
Details
Redox score ?
86
PDB code
7oob
Structure name
pol ii-csb-csa-ddb1-uvssa-adpbef3 (structure2)
Structure deposition date
2021-05-27
Thiol separation (Å)
3
Half-sphere exposure sum ?
58
Minimum pKa ?
6
% buried
10
Peptide accession
P60899
Residue number A
89
Residue number B
114
Peptide name
DNA-directed RNA polymerase II subunit RPB9
Ligandability
Cysteine 89 of DNA-directed RNA polymerase II subunit RPB9
Cysteine 114 of DNA-directed RNA polymerase II subunit RPB9
5iy6 I 86 I 89
A redox-regulated disulphide may form within DNA-directed RNA polymerase II subunit RPB9 between cysteines 86 and 89.
Details
Redox score ?
86
PDB code
5iy6
Structure name
human holo-pic in the closed state
Structure deposition date
2016-03-24
Thiol separation (Å)
3
Half-sphere exposure sum ?
49
Minimum pKa ?
8
% buried
5
Peptide accession
P36954
Residue number A
86
Residue number B
89
Peptide name
DNA-directed RNA polymerase II subunit RPB9
Ligandability
Cysteine 86 of DNA-directed RNA polymerase II subunit RPB9
Cysteine 89 of DNA-directed RNA polymerase II subunit RPB9
7okx I 17 I 39
A redox-regulated disulphide may form within DNA-directed RNA polymerase II subunit RPB9 between cysteines 17 and 39.
Details
Redox score ?
85
PDB code
7okx
Structure name
structure of active transcription elongation complex pol ii-dsif (spt5-kow5)-ell2-eaf1 (composite structure)
Structure deposition date
2021-05-18
Thiol separation (Å)
3
Half-sphere exposure sum ?
58
Minimum pKa ?
6
% buried
60
Peptide accession
P60899
Residue number A
17
Residue number B
39
Peptide name
DNA-directed RNA polymerase II subunit RPB9
Ligandability
Cysteine 17 of DNA-directed RNA polymerase II subunit RPB9
Cysteine 39 of DNA-directed RNA polymerase II subunit RPB9
7edx w 39 w 42
A redox-regulated disulphide may form within DNA-directed RNA polymerase II subunit RPB9 between cysteines 39 and 42.
Details
Redox score ?
83
PDB code
7edx
Structure name
p53-bound tfiid-based core pic on hdm2 promoter
Structure deposition date
2021-03-17
Thiol separation (Å)
3
Half-sphere exposure sum ?
47
Minimum pKa ?
9
% buried
24
Peptide accession
P60899
Residue number A
39
Residue number B
42
Peptide name
DNA-directed RNA polymerase II subunit RPB9
Ligandability
Cysteine 39 of DNA-directed RNA polymerase II subunit RPB9
Cysteine 42 of DNA-directed RNA polymerase II subunit RPB9
7b7u I 20 I 39
A redox-regulated disulphide may form within DNA-directed RNA polymerase II subunit RPB9 between cysteines 20 and 39.
Details
Redox score ?
81
PDB code
7b7u
Structure name
cryo-em structure of mammalian rna polymerase ii in complex with human rpap2
Structure deposition date
2020-12-11
Thiol separation (Å)
3
Half-sphere exposure sum ?
48
Minimum pKa ?
9
% buried
26
Peptide accession
P60899
Residue number A
20
Residue number B
39
Peptide name
DNA-directed RNA polymerase II subunit RPB9
Ligandability
Cysteine 20 of DNA-directed RNA polymerase II subunit RPB9
Cysteine 39 of DNA-directed RNA polymerase II subunit RPB9
5oik I 114 I 119
A redox-regulated disulphide may form within DNA-directed RNA polymerase II subunit RPB9 between cysteines 114 and 119.
Details
Redox score ?
79
PDB code
5oik
Structure name
structure of an rna polymerase ii-dsif transcription elongation complex
Structure deposition date
2017-07-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
8
% buried
10
Peptide accession
Q32P73
Residue number A
114
Residue number B
119
Peptide name
DNA-directed RNA polymerase II subunit RPB9
Ligandability
Cysteine 114 of DNA-directed RNA polymerase II subunit RPB9
Cysteine 119 of DNA-directed RNA polymerase II subunit RPB9
5iya I 20 I 42
A redox-regulated disulphide may form within DNA-directed RNA polymerase II subunit RPB9 between cysteines 20 and 42.
Details
Redox score ?
69
PDB code
5iya
Structure name
human core-pic in the closed state
Structure deposition date
2016-03-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
12
% buried
44
Peptide accession
P36954
Residue number A
20
Residue number B
42
Peptide name
DNA-directed RNA polymerase II subunit RPB9
Ligandability
Cysteine 20 of DNA-directed RNA polymerase II subunit RPB9
Cysteine 42 of DNA-directed RNA polymerase II subunit RPB9
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