Phospholipid hydroperoxide glutathione peroxidase

Intermolecular

Intramolecular

A redox-regulated disulphide may form between two units of Phospholipid hydroperoxide glutathione peroxidase at cysteines 37 and 37 (10 and 10 respectively in this structure).

Details

Redox score ?

PDB code

7u4i

Structure name

crystal structure of human gpx4-u46c-r152h in complex with cds9

Structure deposition date

2022-02-28

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide A name

Phospholipid hydroperoxide glutathione peroxidase

Peptide B name

Phospholipid hydroperoxide glutathione peroxidase

Peptide A accession

P36969

Peptide B accession

P36969

Peptide A residue number

Peptide B residue number

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Phospholipid hydroperoxide glutathione peroxidase at cysteines 93 and 37 (66 and 10 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

7u4l

Structure name

crystal structure of human gpx4-u46c in complex with mac-5576

Structure deposition date

2022-02-28

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide A name

Phospholipid hydroperoxide glutathione peroxidase

Peptide B name

Phospholipid hydroperoxide glutathione peroxidase

Peptide A accession

P36969

Peptide B accession

P36969

Peptide A residue number

Peptide B residue number

Ligandability

Cysteine 93 of Phospholipid hydroperoxide glutathione peroxidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 37 of Phospholipid hydroperoxide glutathione peroxidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phospholipid hydroperoxide glutathione peroxidase between cysteines 102 and 134 (75 and 107 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?