Serine/threonine-protein kinase receptor R3
Intermolecular
Cysteine 443 and cysteine 389
Intramolecular
Cysteine 36 and cysteine 41
Cysteine 34 and cysteine 51
Cysteine 77 and cysteine 89
Cysteine 90 and cysteine 95
Cysteine 46 and cysteine 69
Cysteine 51 and cysteine 95
Cysteine 34 and cysteine 69
Cysteine 36 and cysteine 46
Cysteine 34 and cysteine 46
More...Cysteine 41 and cysteine 46
Cysteine 51 and cysteine 90
Cysteine 34 and cysteine 95
Cysteine 36 and cysteine 69
Cysteine 51 and cysteine 69
Cysteine 46 and cysteine 51
Cysteine 34 and cysteine 90
Cysteine 41 and cysteine 69
Cysteine 89 and cysteine 90
Cysteine 34 and cysteine 36
Cysteine 51 and cysteine 89
Cysteine 34 and cysteine 41
Cysteine 89 and cysteine 95
Cysteine 77 and cysteine 90
Cysteine 34 and cysteine 89
Cysteine 36 and cysteine 51
Cysteine 344 and cysteine 345
Cysteine 69 and cysteine 95
Cysteine 41 and cysteine 51
Cysteine 51 and cysteine 77
Cysteine 46 and cysteine 95
Cysteine 308 and cysteine 344
Cysteine 69 and cysteine 90
3my0 C 443 G 389
A redox-regulated disulphide may form between two units of Serine/threonine-protein kinase receptor R3 at cysteines 443 and 389. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
3my0
Structure name
crystal structure of the acvrl1 (alk1) kinase domain bound to ldn- 193189
Structure deposition date
2010-05-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
70
Peptide A name
Serine/threonine-protein kinase receptor R3
Peptide B name
Serine/threonine-protein kinase receptor R3
Peptide A accession
P37023
Peptide B accession
P37023
Peptide A residue number
443
Peptide B residue number
389
Ligandability
Cysteine 443 of Serine/threonine-protein kinase receptor R3
Cysteine 389 of Serine/threonine-protein kinase receptor R3
4fao U 36 U 41
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 36 and 41.
Details
Redox score ?
88
PDB code
4fao
Structure name
specificity and structure of a high affinity activin-like 1 (alk1) signaling complex
Structure deposition date
2012-05-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
36
Residue number B
41
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 36 of Serine/threonine-protein kinase receptor R3
Cysteine 41 of Serine/threonine-protein kinase receptor R3
4fao P 34 P 51
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 34 and 51.
Details
Redox score ?
84
PDB code
4fao
Structure name
specificity and structure of a high affinity activin-like 1 (alk1) signaling complex
Structure deposition date
2012-05-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
34
Residue number B
51
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 34 of Serine/threonine-protein kinase receptor R3
Cysteine 51 of Serine/threonine-protein kinase receptor R3
4fao C 77 C 89
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 77 and 89.
Details
Redox score ?
84
PDB code
4fao
Structure name
specificity and structure of a high affinity activin-like 1 (alk1) signaling complex
Structure deposition date
2012-05-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
77
Residue number B
89
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 77 of Serine/threonine-protein kinase receptor R3
Cysteine 89 of Serine/threonine-protein kinase receptor R3
4fao j 90 j 95
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 90 and 95.
Details
Redox score ?
79
PDB code
4fao
Structure name
specificity and structure of a high affinity activin-like 1 (alk1) signaling complex
Structure deposition date
2012-05-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
90
Residue number B
95
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 90 of Serine/threonine-protein kinase receptor R3
Cysteine 95 of Serine/threonine-protein kinase receptor R3
6sf3 A 46 A 69
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 46 and 69.
Details
Redox score ?
75
PDB code
6sf3
Structure name
bone morphogenetic protein 10 (bmp10) in complex with extracellular domain of activin receptor-like kinase 1 (alk1) at 2
Structure deposition date
2019-07-31
Thiol separation (Å)
3
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
20
Peptide accession
P37023
Residue number A
46
Residue number B
69
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 46 of Serine/threonine-protein kinase receptor R3
Cysteine 69 of Serine/threonine-protein kinase receptor R3
7ppc F 51 F 95
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 51 and 95.
Details
Redox score ?
72
PDB code
7ppc
Structure name
ternary signalling complex of bmp10 bound to alk1 and bmprii
Structure deposition date
2021-09-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
51
Residue number B
95
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 51 of Serine/threonine-protein kinase receptor R3
Cysteine 95 of Serine/threonine-protein kinase receptor R3
7ppc E 34 E 69
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 34 and 69.
Details
Redox score ?
71
PDB code
7ppc
Structure name
ternary signalling complex of bmp10 bound to alk1 and bmprii
Structure deposition date
2021-09-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
34
Residue number B
69
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 34 of Serine/threonine-protein kinase receptor R3
Cysteine 69 of Serine/threonine-protein kinase receptor R3
7ppc F 36 F 46
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 36 and 46.
Details
Redox score ?
70
PDB code
7ppc
Structure name
ternary signalling complex of bmp10 bound to alk1 and bmprii
Structure deposition date
2021-09-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
36
Residue number B
46
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 36 of Serine/threonine-protein kinase receptor R3
Cysteine 46 of Serine/threonine-protein kinase receptor R3
7ppc G 34 G 46
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 34 and 46.
Details
Redox score ?
68
PDB code
7ppc
Structure name
ternary signalling complex of bmp10 bound to alk1 and bmprii
Structure deposition date
2021-09-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
34
Residue number B
46
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 34 of Serine/threonine-protein kinase receptor R3
Cysteine 46 of Serine/threonine-protein kinase receptor R3
4fao D 41 D 46
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 41 and 46.
Details
Redox score ?
64
PDB code
4fao
Structure name
specificity and structure of a high affinity activin-like 1 (alk1) signaling complex
Structure deposition date
2012-05-22
Thiol separation (Å)
6
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
41
Residue number B
46
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 41 of Serine/threonine-protein kinase receptor R3
Cysteine 46 of Serine/threonine-protein kinase receptor R3
6sf2 D 51 D 90
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 51 and 90.
Details
Redox score ?
64
PDB code
6sf2
Structure name
ternary complex of human bone morphogenetic protein 9 (bmp9) growth factor domain, its prodomain and extracellular domain of activin receptor-like kinase 1 (alk1)
Structure deposition date
2019-07-31
Thiol separation (Å)
5
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
51
Residue number B
90
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 51 of Serine/threonine-protein kinase receptor R3
Cysteine 90 of Serine/threonine-protein kinase receptor R3
4fao d 34 d 95
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 34 and 95. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
4fao
Structure name
specificity and structure of a high affinity activin-like 1 (alk1) signaling complex
Structure deposition date
2012-05-22
Thiol separation (Å)
6
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
34
Residue number B
95
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 34 of Serine/threonine-protein kinase receptor R3
Cysteine 95 of Serine/threonine-protein kinase receptor R3
6sf2 D 36 D 69
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 36 and 69. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
6sf2
Structure name
ternary complex of human bone morphogenetic protein 9 (bmp9) growth factor domain, its prodomain and extracellular domain of activin receptor-like kinase 1 (alk1)
Structure deposition date
2019-07-31
Thiol separation (Å)
6
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
36
Residue number B
69
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 36 of Serine/threonine-protein kinase receptor R3
Cysteine 69 of Serine/threonine-protein kinase receptor R3
4fao J 51 J 69
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 51 and 69. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
4fao
Structure name
specificity and structure of a high affinity activin-like 1 (alk1) signaling complex
Structure deposition date
2012-05-22
Thiol separation (Å)
6
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
51
Residue number B
69
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 51 of Serine/threonine-protein kinase receptor R3
Cysteine 69 of Serine/threonine-protein kinase receptor R3
4fao C 46 C 51
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 46 and 51. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
4fao
Structure name
specificity and structure of a high affinity activin-like 1 (alk1) signaling complex
Structure deposition date
2012-05-22
Thiol separation (Å)
7
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
46
Residue number B
51
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 46 of Serine/threonine-protein kinase receptor R3
Cysteine 51 of Serine/threonine-protein kinase receptor R3
4fao D 34 D 90
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 34 and 90. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
4fao
Structure name
specificity and structure of a high affinity activin-like 1 (alk1) signaling complex
Structure deposition date
2012-05-22
Thiol separation (Å)
7
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
34
Residue number B
90
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 34 of Serine/threonine-protein kinase receptor R3
Cysteine 90 of Serine/threonine-protein kinase receptor R3
7ppc H 41 H 69
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 41 and 69. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
7ppc
Structure name
ternary signalling complex of bmp10 bound to alk1 and bmprii
Structure deposition date
2021-09-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
41
Residue number B
69
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 41 of Serine/threonine-protein kinase receptor R3
Cysteine 69 of Serine/threonine-protein kinase receptor R3
6sf3 A 89 A 90
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 89 and 90. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6sf3
Structure name
bone morphogenetic protein 10 (bmp10) in complex with extracellular domain of activin receptor-like kinase 1 (alk1) at 2
Structure deposition date
2019-07-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
89
Residue number B
90
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 89 of Serine/threonine-protein kinase receptor R3
Cysteine 90 of Serine/threonine-protein kinase receptor R3
7ppc E 34 E 36
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 34 and 36. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
7ppc
Structure name
ternary signalling complex of bmp10 bound to alk1 and bmprii
Structure deposition date
2021-09-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
34
Residue number B
36
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 34 of Serine/threonine-protein kinase receptor R3
Cysteine 36 of Serine/threonine-protein kinase receptor R3
7ppc G 51 G 89
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 51 and 89. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7ppc
Structure name
ternary signalling complex of bmp10 bound to alk1 and bmprii
Structure deposition date
2021-09-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
51
Residue number B
89
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 51 of Serine/threonine-protein kinase receptor R3
Cysteine 89 of Serine/threonine-protein kinase receptor R3
6sf2 A 34 A 41
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 34 and 41. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
6sf2
Structure name
ternary complex of human bone morphogenetic protein 9 (bmp9) growth factor domain, its prodomain and extracellular domain of activin receptor-like kinase 1 (alk1)
Structure deposition date
2019-07-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
34
Residue number B
41
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 34 of Serine/threonine-protein kinase receptor R3
Cysteine 41 of Serine/threonine-protein kinase receptor R3
7ppc E 89 E 95
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 89 and 95. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7ppc
Structure name
ternary signalling complex of bmp10 bound to alk1 and bmprii
Structure deposition date
2021-09-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
89
Residue number B
95
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 89 of Serine/threonine-protein kinase receptor R3
Cysteine 95 of Serine/threonine-protein kinase receptor R3
4fao C 77 C 90
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 77 and 90. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
4fao
Structure name
specificity and structure of a high affinity activin-like 1 (alk1) signaling complex
Structure deposition date
2012-05-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
77
Residue number B
90
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 77 of Serine/threonine-protein kinase receptor R3
Cysteine 90 of Serine/threonine-protein kinase receptor R3
6sf1 A 34 A 89
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 34 and 89. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
6sf1
Structure name
bone morphogenetic protein 10 (bmp10) complexed with extracellular domain of activin receptor-like kinase 1 (alk1)
Structure deposition date
2019-07-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
34
Residue number B
89
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 34 of Serine/threonine-protein kinase receptor R3
Cysteine 89 of Serine/threonine-protein kinase receptor R3
4fao J 36 J 51
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 36 and 51. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
4fao
Structure name
specificity and structure of a high affinity activin-like 1 (alk1) signaling complex
Structure deposition date
2012-05-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
36
Residue number B
51
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 36 of Serine/threonine-protein kinase receptor R3
Cysteine 51 of Serine/threonine-protein kinase receptor R3
3my0 P 344 P 345
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 344 and 345. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
3my0
Structure name
crystal structure of the acvrl1 (alk1) kinase domain bound to ldn- 193189
Structure deposition date
2010-05-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
94
Peptide accession
P37023
Residue number A
344
Residue number B
345
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 344 of Serine/threonine-protein kinase receptor R3
Cysteine 345 of Serine/threonine-protein kinase receptor R3
7ppc H 69 H 95
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 69 and 95. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
7ppc
Structure name
ternary signalling complex of bmp10 bound to alk1 and bmprii
Structure deposition date
2021-09-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
69
Residue number B
95
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 69 of Serine/threonine-protein kinase receptor R3
Cysteine 95 of Serine/threonine-protein kinase receptor R3
2lcr A 20 A 30
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 41 and 51 (20 and 30 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
2lcr
Structure name
nmr structure of alk1 extracellular domain
Structure deposition date
2011-05-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
41
Residue number B
51
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 41 of Serine/threonine-protein kinase receptor R3
Cysteine 51 of Serine/threonine-protein kinase receptor R3
2lcr A 30 A 56
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 51 and 77 (30 and 56 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
2lcr
Structure name
nmr structure of alk1 extracellular domain
Structure deposition date
2011-05-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
51
Residue number B
77
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 51 of Serine/threonine-protein kinase receptor R3
Cysteine 77 of Serine/threonine-protein kinase receptor R3
7ppc H 46 H 95
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 46 and 95. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
7ppc
Structure name
ternary signalling complex of bmp10 bound to alk1 and bmprii
Structure deposition date
2021-09-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
46
Residue number B
95
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 46 of Serine/threonine-protein kinase receptor R3
Cysteine 95 of Serine/threonine-protein kinase receptor R3
3my0 P 308 P 344
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 308 and 344. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
3my0
Structure name
crystal structure of the acvrl1 (alk1) kinase domain bound to ldn- 193189
Structure deposition date
2010-05-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
10
% buried
72
Peptide accession
P37023
Residue number A
308
Residue number B
344
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 308 of Serine/threonine-protein kinase receptor R3
Cysteine 344 of Serine/threonine-protein kinase receptor R3
7ppc F 69 F 90
A redox-regulated disulphide may form within Serine/threonine-protein kinase receptor R3 between cysteines 69 and 90. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
7ppc
Structure name
ternary signalling complex of bmp10 bound to alk1 and bmprii
Structure deposition date
2021-09-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37023
Residue number A
69
Residue number B
90
Peptide name
Serine/threonine-protein kinase receptor R3
Ligandability
Cysteine 69 of Serine/threonine-protein kinase receptor R3
Cysteine 90 of Serine/threonine-protein kinase receptor R3
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