Amiloride-sensitive sodium channel subunit alpha
Intramolecular
Cysteine 229 and cysteine 236
Cysteine 429 and cysteine 456
Cysteine 416 and cysteine 475
Cysteine 394 and cysteine 479
Cysteine 133 and cysteine 305
Cysteine 431 and cysteine 445
Cysteine 420 and cysteine 471
Cysteine 282 and cysteine 289
Cysteine 420 and cysteine 475
Cysteine 471 and cysteine 475
More...Cysteine 429 and cysteine 431
Cysteine 416 and cysteine 420
Cysteine 429 and cysteine 445
Cysteine 416 and cysteine 471
Cysteine 431 and cysteine 456
Cysteine 445 and cysteine 456
6wth A 229 A 236
A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit alpha between cysteines 229 and 236.
Details
Redox score ?
86
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37088
Residue number A
229
Residue number B
236
Peptide name
Amiloride-sensitive sodium channel subunit alpha
Ligandability
Cysteine 229 of Amiloride-sensitive sodium channel subunit alpha
Cysteine 236 of Amiloride-sensitive sodium channel subunit alpha
6wth A 429 A 456
A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit alpha between cysteines 429 and 456.
Details
Redox score ?
83
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37088
Residue number A
429
Residue number B
456
Peptide name
Amiloride-sensitive sodium channel subunit alpha
Ligandability
Cysteine 429 of Amiloride-sensitive sodium channel subunit alpha
Cysteine 456 of Amiloride-sensitive sodium channel subunit alpha
6wth A 416 A 475
A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit alpha between cysteines 416 and 475.
Details
Redox score ?
83
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37088
Residue number A
416
Residue number B
475
Peptide name
Amiloride-sensitive sodium channel subunit alpha
Ligandability
Cysteine 416 of Amiloride-sensitive sodium channel subunit alpha
Cysteine 475 of Amiloride-sensitive sodium channel subunit alpha
6wth A 394 A 479
A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit alpha between cysteines 394 and 479.
Details
Redox score ?
83
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37088
Residue number A
394
Residue number B
479
Peptide name
Amiloride-sensitive sodium channel subunit alpha
Ligandability
Cysteine 394 of Amiloride-sensitive sodium channel subunit alpha
Cysteine 479 of Amiloride-sensitive sodium channel subunit alpha
6wth A 133 A 305
A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit alpha between cysteines 133 and 305.
Details
Redox score ?
82
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37088
Residue number A
133
Residue number B
305
Peptide name
Amiloride-sensitive sodium channel subunit alpha
Ligandability
Cysteine 133 of Amiloride-sensitive sodium channel subunit alpha
Cysteine 305 of Amiloride-sensitive sodium channel subunit alpha
6wth A 431 A 445
A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit alpha between cysteines 431 and 445.
Details
Redox score ?
81
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37088
Residue number A
431
Residue number B
445
Peptide name
Amiloride-sensitive sodium channel subunit alpha
Ligandability
Cysteine 431 of Amiloride-sensitive sodium channel subunit alpha
Cysteine 445 of Amiloride-sensitive sodium channel subunit alpha
6wth A 420 A 471
A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit alpha between cysteines 420 and 471.
Details
Redox score ?
80
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37088
Residue number A
420
Residue number B
471
Peptide name
Amiloride-sensitive sodium channel subunit alpha
Ligandability
Cysteine 420 of Amiloride-sensitive sodium channel subunit alpha
Cysteine 471 of Amiloride-sensitive sodium channel subunit alpha
6wth A 282 A 289
A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit alpha between cysteines 282 and 289.
Details
Redox score ?
80
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37088
Residue number A
282
Residue number B
289
Peptide name
Amiloride-sensitive sodium channel subunit alpha
Ligandability
Cysteine 282 of Amiloride-sensitive sodium channel subunit alpha
Cysteine 289 of Amiloride-sensitive sodium channel subunit alpha
6wth A 420 A 475
A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit alpha between cysteines 420 and 475.
Details
Redox score ?
64
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
5
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37088
Residue number A
420
Residue number B
475
Peptide name
Amiloride-sensitive sodium channel subunit alpha
Ligandability
Cysteine 420 of Amiloride-sensitive sodium channel subunit alpha
Cysteine 475 of Amiloride-sensitive sodium channel subunit alpha
6wth A 471 A 475
A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit alpha between cysteines 471 and 475.
Details
Redox score ?
61
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37088
Residue number A
471
Residue number B
475
Peptide name
Amiloride-sensitive sodium channel subunit alpha
Ligandability
Cysteine 471 of Amiloride-sensitive sodium channel subunit alpha
Cysteine 475 of Amiloride-sensitive sodium channel subunit alpha
6wth A 429 A 431
A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit alpha between cysteines 429 and 431.
Details
Redox score ?
60
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37088
Residue number A
429
Residue number B
431
Peptide name
Amiloride-sensitive sodium channel subunit alpha
Ligandability
Cysteine 429 of Amiloride-sensitive sodium channel subunit alpha
Cysteine 431 of Amiloride-sensitive sodium channel subunit alpha
6wth A 416 A 420
A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit alpha between cysteines 416 and 420. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37088
Residue number A
416
Residue number B
420
Peptide name
Amiloride-sensitive sodium channel subunit alpha
Ligandability
Cysteine 416 of Amiloride-sensitive sodium channel subunit alpha
Cysteine 420 of Amiloride-sensitive sodium channel subunit alpha
6wth A 429 A 445
A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit alpha between cysteines 429 and 445. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
7
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37088
Residue number A
429
Residue number B
445
Peptide name
Amiloride-sensitive sodium channel subunit alpha
Ligandability
Cysteine 429 of Amiloride-sensitive sodium channel subunit alpha
Cysteine 445 of Amiloride-sensitive sodium channel subunit alpha
6wth A 416 A 471
A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit alpha between cysteines 416 and 471. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37088
Residue number A
416
Residue number B
471
Peptide name
Amiloride-sensitive sodium channel subunit alpha
Ligandability
Cysteine 416 of Amiloride-sensitive sodium channel subunit alpha
Cysteine 471 of Amiloride-sensitive sodium channel subunit alpha
6wth A 431 A 456
A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit alpha between cysteines 431 and 456. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
7
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37088
Residue number A
431
Residue number B
456
Peptide name
Amiloride-sensitive sodium channel subunit alpha
Ligandability
Cysteine 431 of Amiloride-sensitive sodium channel subunit alpha
Cysteine 456 of Amiloride-sensitive sodium channel subunit alpha
6wth A 445 A 456
A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit alpha between cysteines 445 and 456. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37088
Residue number A
445
Residue number B
456
Peptide name
Amiloride-sensitive sodium channel subunit alpha
Ligandability
Cysteine 445 of Amiloride-sensitive sodium channel subunit alpha
Cysteine 456 of Amiloride-sensitive sodium channel subunit alpha
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