ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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TGF-beta receptor type-2

Intramolecular
Cysteine 54 and cysteine 71
Cysteine 61 and cysteine 67
Cysteine 77 and cysteine 101
Cysteine 121 and cysteine 136
Cysteine 51 and cysteine 84
Cysteine 138 and cysteine 143
Cysteine 51 and cysteine 77
Cysteine 121 and cysteine 138
Cysteine 51 and cysteine 101
Cysteine 84 and cysteine 143
More...
Cysteine 77 and cysteine 84
Cysteine 84 and cysteine 138
Cysteine 121 and cysteine 143
Cysteine 51 and cysteine 143
Cysteine 84 and cysteine 101
Cysteine 136 and cysteine 138
Cysteine 51 and cysteine 138
Cysteine 520 and cysteine 533
Cysteine 84 and cysteine 121
Cysteine 394 and cysteine 396
Cysteine 67 and cysteine 121
Cysteine 51 and cysteine 71
Cysteine 136 and cysteine 143
Cysteine 51 and cysteine 121
Cysteine 51 and cysteine 54
Cysteine 77 and cysteine 143
Cysteine 101 and cysteine 138
Cysteine 54 and cysteine 84
Cysteine 77 and cysteine 138
Cysteine 51 and cysteine 136
Cysteine 61 and cysteine 136
Cysteine 461 and cysteine 514
Cysteine 84 and cysteine 136
Cysteine 101 and cysteine 143
Cysteine 393 and cysteine 394
A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 54 and 71 (31 and 48 respectively in this structure).

Details

Redox score ?
84
PDB code
3kfd
Structure name
ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Structure deposition date
2009-10-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
54
Residue number B
71
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 54 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 71 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 61 and 67 (38 and 44 respectively in this structure).

Details

Redox score ?
83
PDB code
3kfd
Structure name
ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Structure deposition date
2009-10-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
61
Residue number B
67
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 61 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 67 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 77 and 101 (54 and 78 respectively in this structure).

Details

Redox score ?
82
PDB code
3kfd
Structure name
ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Structure deposition date
2009-10-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
77
Residue number B
101
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 77 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 101 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 121 and 136 (98 and 113 respectively in this structure).

Details

Redox score ?
80
PDB code
1ktz
Structure name
crystal structure of the human tgf-beta type ii receptor extracellular domain in complex with tgf-beta3
Structure deposition date
2002-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
121
Residue number B
136
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 121 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 136 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 51 and 84 (28 and 61 respectively in this structure).

Details

Redox score ?
78
PDB code
3kfd
Structure name
ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Structure deposition date
2009-10-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
96
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
51
Residue number B
84
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 51 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 84 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 138 and 143 (115 and 120 respectively in this structure).

Details

Redox score ?
78
PDB code
3kfd
Structure name
ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Structure deposition date
2009-10-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
138
Residue number B
143
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 138 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 143 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 51 and 77 (28 and 54 respectively in this structure).

Details

Redox score ?
72
PDB code
2pjy
Structure name
structural basis for cooperative assembly of the tgf-beta signaling complex
Structure deposition date
2007-04-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
51
Residue number B
77
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 51 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 77 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 121 and 138 (98 and 115 respectively in this structure).

Details

Redox score ?
70
PDB code
3kfd
Structure name
ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Structure deposition date
2009-10-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
121
Residue number B
138
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 121 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 138 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 51 and 101 (28 and 78 respectively in this structure).

Details

Redox score ?
70
PDB code
3kfd
Structure name
ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Structure deposition date
2009-10-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
90
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
51
Residue number B
101
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 51 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 101 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 84 and 143 (61 and 120 respectively in this structure).

Details

Redox score ?
69
PDB code
3kfd
Structure name
ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Structure deposition date
2009-10-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
84
Residue number B
143
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 84 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 143 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 77 and 84 (54 and 61 respectively in this structure).

Details

Redox score ?
64
PDB code
4p7u
Structure name
extracellular domain of type ii transforming growth factor beta receptor in complex with ndsb-201
Structure deposition date
2014-03-27
Thiol separation (Å)
5
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
77
Residue number B
84
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 77 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 84 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 84 and 138 (61 and 115 respectively in this structure).

Details

Redox score ?
60
PDB code
3kfd
Structure name
ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Structure deposition date
2009-10-27
Thiol separation (Å)
5
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
84
Residue number B
138
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 84 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 138 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 121 and 143 (98 and 120 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
4xjj
Structure name
extracellular domain of type ii transforming growth factor beta receptor in complex with 2-(2-hydroxyethyl)ndsb-201
Structure deposition date
2015-01-08
Thiol separation (Å)
6
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
121
Residue number B
143
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 121 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 143 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 51 and 143 (28 and 120 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
1ktz
Structure name
crystal structure of the human tgf-beta type ii receptor extracellular domain in complex with tgf-beta3
Structure deposition date
2002-01-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
51
Residue number B
143
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 51 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 143 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 84 and 101 (61 and 78 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
4p7u
Structure name
extracellular domain of type ii transforming growth factor beta receptor in complex with ndsb-201
Structure deposition date
2014-03-27
Thiol separation (Å)
6
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
84
Residue number B
101
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 84 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 101 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 136 and 138 (113 and 115 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
3kfd
Structure name
ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Structure deposition date
2009-10-27
Thiol separation (Å)
6
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
136
Residue number B
138
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 136 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 138 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 51 and 138 (28 and 115 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
1ktz
Structure name
crystal structure of the human tgf-beta type ii receptor extracellular domain in complex with tgf-beta3
Structure deposition date
2002-01-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
51
Residue number B
138
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 51 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 138 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 520 and 533. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
7dv6
Structure name
discovery of functionally selective transforming growth factor beta type ii receptor (tgf-beta rii) inhibitors as anti-fibrosis agents
Structure deposition date
2021-01-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
62
Minimum pKa ?
9
% buried
56
Peptide accession
P37173
Residue number A
520
Residue number B
533
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 520 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 533 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 84 and 121 (61 and 98 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
3kfd
Structure name
ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Structure deposition date
2009-10-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
91
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
84
Residue number B
121
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 84 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 121 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 394 and 396. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
5e8y
Structure name
tgf-beta receptor type 2 kinase domain (e431a,r433a,e485a,k488a,r493a, r495a) in complex with staurosporine
Structure deposition date
2015-10-14
Thiol separation (Å)
6
Half-sphere exposure sum ?
92
Minimum pKa ?
12
% buried
97
Peptide accession
P37173
Residue number A
394
Residue number B
396
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 394 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 396 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 67 and 121. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
5ty4
Structure name
microed structure of a complex between monomeric tgf-b and its receptor, tbrii, at 2
Structure deposition date
2016-11-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
67
Residue number B
121
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 67 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 121 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 51 and 71 (28 and 48 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
1plo
Structure name
transforming growth factor-beta type ii receptor extracellular domain
Structure deposition date
2003-06-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
51
Residue number B
71
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 51 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 71 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 136 and 143 (113 and 120 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
1m9z
Structure name
crystal structure of human tgf-beta type ii receptor ligand binding domain
Structure deposition date
2002-07-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
136
Residue number B
143
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 136 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 143 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 51 and 121 (28 and 98 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
5tx4
Structure name
derivative of mouse tgf-beta2, with a deletion of residues 52-71 and k25r, r26k, l51r, a74k, c77s, l89v, i92v, k94r t95k, i98v single amino acid substitutions, bound to human tgf-beta type ii receptor ectodomain residues 15-130
Structure deposition date
2016-11-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
51
Residue number B
121
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 51 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 121 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 51 and 54 (28 and 31 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
1plo
Structure name
transforming growth factor-beta type ii receptor extracellular domain
Structure deposition date
2003-06-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
51
Residue number B
54
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 51 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 54 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 77 and 143 (54 and 120 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
3kfd
Structure name
ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Structure deposition date
2009-10-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
77
Residue number B
143
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 77 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 143 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 101 and 138 (78 and 115 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
1plo
Structure name
transforming growth factor-beta type ii receptor extracellular domain
Structure deposition date
2003-06-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
101
Residue number B
138
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 101 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 138 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 54 and 84 (31 and 61 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
1plo
Structure name
transforming growth factor-beta type ii receptor extracellular domain
Structure deposition date
2003-06-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
54
Residue number B
84
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 54 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 84 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 77 and 138 (54 and 115 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
4xjj
Structure name
extracellular domain of type ii transforming growth factor beta receptor in complex with 2-(2-hydroxyethyl)ndsb-201
Structure deposition date
2015-01-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
77
Residue number B
138
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 77 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 138 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 51 and 136 (28 and 113 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
1plo
Structure name
transforming growth factor-beta type ii receptor extracellular domain
Structure deposition date
2003-06-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
51
Residue number B
136
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 51 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 136 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 61 and 136 (38 and 113 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
4xjj
Structure name
extracellular domain of type ii transforming growth factor beta receptor in complex with 2-(2-hydroxyethyl)ndsb-201
Structure deposition date
2015-01-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
61
Residue number B
136
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 61 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 136 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 461 and 514. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
5e8y
Structure name
tgf-beta receptor type 2 kinase domain (e431a,r433a,e485a,k488a,r493a, r495a) in complex with staurosporine
Structure deposition date
2015-10-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
60
Peptide accession
P37173
Residue number A
461
Residue number B
514
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 461 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 514 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 84 and 136 (61 and 113 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
5tx4
Structure name
derivative of mouse tgf-beta2, with a deletion of residues 52-71 and k25r, r26k, l51r, a74k, c77s, l89v, i92v, k94r t95k, i98v single amino acid substitutions, bound to human tgf-beta type ii receptor ectodomain residues 15-130
Structure deposition date
2016-11-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
97
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
84
Residue number B
136
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 84 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 136 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 101 and 143 (78 and 120 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
4p7u
Structure name
extracellular domain of type ii transforming growth factor beta receptor in complex with ndsb-201
Structure deposition date
2014-03-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P37173
Residue number A
101
Residue number B
143
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 101 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 143 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TGF-beta receptor type-2 between cysteines 393 and 394. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
5e91
Structure name
tgf-beta receptor type 2 kinase domain (e431a,r433a,e485a,k488a,r493a, r495a) in complex with 3-amino-6-[4-(2- hydroxyethyl)phenyl]-n-[4- (morpholin-4-yl)pyridin-3-yl] pyrazine-2-carboxamide
Structure deposition date
2015-10-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
96
Peptide accession
P37173
Residue number A
393
Residue number B
394
Peptide name
TGF-beta receptor type-2

Ligandability

Cysteine 393 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 394 of TGF-beta receptor type-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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