ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interferon gamma receptor 2

Intramolecular
Cysteine 174 and cysteine 308
Cysteine 174 and cysteine 312
Cysteine 209 and cysteine 234
Cysteine 86 and cysteine 94
A redox-regulated disulphide may form within Interferon gamma receptor 2 between cysteines 174 and 308.

Details

Redox score ?
86
PDB code
6e3l
Structure name
interferon gamma signalling complex with ifngr1 and ifngr2
Structure deposition date
2018-07-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P38484
Residue number A
174
Residue number B
308
Peptide name
Interferon gamma receptor 2

Ligandability

Cysteine 174 of Interferon gamma receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 308 of Interferon gamma receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 308 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Interferon gamma receptor 2 between cysteines 174 and 312.

Details

Redox score ?
86
PDB code
6e3l
Structure name
interferon gamma signalling complex with ifngr1 and ifngr2
Structure deposition date
2018-07-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P38484
Residue number A
174
Residue number B
312
Peptide name
Interferon gamma receptor 2

Ligandability

Cysteine 174 of Interferon gamma receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 312 of Interferon gamma receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 312 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Interferon gamma receptor 2 between cysteines 209 and 234.

Details

Redox score ?
81
PDB code
6e3l
Structure name
interferon gamma signalling complex with ifngr1 and ifngr2
Structure deposition date
2018-07-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P38484
Residue number A
209
Residue number B
234
Peptide name
Interferon gamma receptor 2

Ligandability

Cysteine 209 of Interferon gamma receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 234 of Interferon gamma receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon gamma receptor 2 between cysteines 86 and 94.

Details

Redox score ?
72
PDB code
6e3k
Structure name
interferon gamma signalling complex with ifngr1 and ifngr2
Structure deposition date
2018-07-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
8
% buried
79
Peptide accession
P38484
Residue number A
86
Residue number B
94
Peptide name
Interferon gamma receptor 2

Ligandability

Cysteine 86 of Interferon gamma receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 94 of Interferon gamma receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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