ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Flap endonuclease 1

Intramolecular
Cysteine 163 and cysteine 182 L
A redox-regulated disulphide may form within Flap endonuclease 1 between cysteines 163 and 182. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
3q8m
Structure name
crystal structure of human flap endonuclease fen1 (d181a) in complex with substrate 5'-flap dna and k+
Structure deposition date
2011-01-06
Thiol separation (Å)
6
Half-sphere exposure sum ?
100
Minimum pKa ?
15
% buried
100
Peptide accession
P39748
Residue number A
163
Residue number B
182
Peptide name
Flap endonuclease 1

Ligandability

Cysteine 163 of Flap endonuclease 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 182 of Flap endonuclease 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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