ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Glial cell line-derived neurotrophic factor

Intermolecular
Cysteine 178 and cysteine 178
Cysteine 210 and cysteine 178
Intramolecular
Cysteine 149 and cysteine 210
Cysteine 118 and cysteine 179
Cysteine 145 and cysteine 208
Cysteine 118 and cysteine 149
Cysteine 118 and cysteine 210
Cysteine 179 and cysteine 208
Cysteine 149 and cysteine 179
Cysteine 118 and cysteine 208
More...
Cysteine 145 and cysteine 179
Cysteine 179 and cysteine 210
Cysteine 118 and cysteine 145
Cysteine 149 and cysteine 178
Cysteine 208 and cysteine 210
Cysteine 149 and cysteine 208
Cysteine 118 and cysteine 178
Cysteine 145 and cysteine 149
Cysteine 178 and cysteine 210
Cysteine 145 and cysteine 210
Cysteine 178 and cysteine 179
Cysteine 145 and cysteine 178
A redox-regulated disulphide may form between two units of Glial cell line-derived neurotrophic factor at cysteines 178 and 178 (101 and 101 respectively in this structure).

Details

Redox score ?
81
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glial cell line-derived neurotrophic factor
Peptide B name
Glial cell line-derived neurotrophic factor
Peptide A accession
P39905
Peptide B accession
P39905
Peptide A residue number
178
Peptide B residue number
178

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Glial cell line-derived neurotrophic factor at cysteines 210 and 178 (134 and 102 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
1agq
Structure name
glial cell-derived neurotrophic factor from rat
Structure deposition date
1997-03-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glial cell line-derived neurotrophic factor
Peptide B name
Glial cell line-derived neurotrophic factor
Peptide A accession
Q07731
Peptide B accession
Q07731
Peptide A residue number
210
Peptide B residue number
178

Ligandability

Cysteine 210 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 178 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glial cell line-derived neurotrophic factor between cysteines 149 and 210 (72 and 133 respectively in this structure).

Details

Redox score ?
88
PDB code
2v5e
Structure name
the structure of the gdnf:coreceptor complex: insights into ret signalling and heparin binding
Structure deposition date
2008-10-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P39905
Residue number A
149
Residue number B
210
Peptide name
Glial cell line-derived neurotrophic factor

Ligandability

Cysteine 149 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 210 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glial cell line-derived neurotrophic factor between cysteines 118 and 179 (41 and 102 respectively in this structure).

Details

Redox score ?
88
PDB code
2v5e
Structure name
the structure of the gdnf:coreceptor complex: insights into ret signalling and heparin binding
Structure deposition date
2008-10-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P39905
Residue number A
118
Residue number B
179
Peptide name
Glial cell line-derived neurotrophic factor

Ligandability

Cysteine 118 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 179 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glial cell line-derived neurotrophic factor between cysteines 145 and 208 (68 and 131 respectively in this structure).

Details

Redox score ?
88
PDB code
2v5e
Structure name
the structure of the gdnf:coreceptor complex: insights into ret signalling and heparin binding
Structure deposition date
2008-10-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P39905
Residue number A
145
Residue number B
208
Peptide name
Glial cell line-derived neurotrophic factor

Ligandability

Cysteine 145 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 208 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glial cell line-derived neurotrophic factor between cysteines 118 and 149 (41 and 72 respectively in this structure).

Details

Redox score ?
76
PDB code
3fub
Structure name
crystal structure of gdnf-gfralpha1 complex
Structure deposition date
2009-01-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P39905
Residue number A
118
Residue number B
149
Peptide name
Glial cell line-derived neurotrophic factor

Ligandability

Cysteine 118 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 149 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glial cell line-derived neurotrophic factor between cysteines 118 and 210 (42 and 134 respectively in this structure).

Details

Redox score ?
73
PDB code
1agq
Structure name
glial cell-derived neurotrophic factor from rat
Structure deposition date
1997-03-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07731
Residue number A
118
Residue number B
210
Peptide name
Glial cell line-derived neurotrophic factor

Ligandability

Cysteine 118 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 210 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glial cell line-derived neurotrophic factor between cysteines 179 and 208 (102 and 131 respectively in this structure).

Details

Redox score ?
71
PDB code
2v5e
Structure name
the structure of the gdnf:coreceptor complex: insights into ret signalling and heparin binding
Structure deposition date
2008-10-03
Thiol separation (Å)
5
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P39905
Residue number A
179
Residue number B
208
Peptide name
Glial cell line-derived neurotrophic factor

Ligandability

Cysteine 179 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 208 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glial cell line-derived neurotrophic factor between cysteines 149 and 179 (72 and 102 respectively in this structure).

Details

Redox score ?
70
PDB code
2v5e
Structure name
the structure of the gdnf:coreceptor complex: insights into ret signalling and heparin binding
Structure deposition date
2008-10-03
Thiol separation (Å)
5
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P39905
Residue number A
149
Residue number B
179
Peptide name
Glial cell line-derived neurotrophic factor

Ligandability

Cysteine 149 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 179 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glial cell line-derived neurotrophic factor between cysteines 118 and 208 (42 and 132 respectively in this structure).

Details

Redox score ?
70
PDB code
1agq
Structure name
glial cell-derived neurotrophic factor from rat
Structure deposition date
1997-03-25
Thiol separation (Å)
5
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07731
Residue number A
118
Residue number B
208
Peptide name
Glial cell line-derived neurotrophic factor

Ligandability

Cysteine 118 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 208 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glial cell line-derived neurotrophic factor between cysteines 145 and 179 (68 and 102 respectively in this structure).

Details

Redox score ?
70
PDB code
3fub
Structure name
crystal structure of gdnf-gfralpha1 complex
Structure deposition date
2009-01-14
Thiol separation (Å)
5
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P39905
Residue number A
145
Residue number B
179
Peptide name
Glial cell line-derived neurotrophic factor

Ligandability

Cysteine 145 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 179 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glial cell line-derived neurotrophic factor between cysteines 179 and 210 (102 and 133 respectively in this structure).

Details

Redox score ?
69
PDB code
3fub
Structure name
crystal structure of gdnf-gfralpha1 complex
Structure deposition date
2009-01-14
Thiol separation (Å)
5
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P39905
Residue number A
179
Residue number B
210
Peptide name
Glial cell line-derived neurotrophic factor

Ligandability

Cysteine 179 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 210 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glial cell line-derived neurotrophic factor between cysteines 118 and 145 (42 and 69 respectively in this structure).

Details

Redox score ?
66
PDB code
1agq
Structure name
glial cell-derived neurotrophic factor from rat
Structure deposition date
1997-03-25
Thiol separation (Å)
6
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07731
Residue number A
118
Residue number B
145
Peptide name
Glial cell line-derived neurotrophic factor

Ligandability

Cysteine 118 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 145 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glial cell line-derived neurotrophic factor between cysteines 149 and 178 (72 and 101 respectively in this structure).

Details

Redox score ?
60
PDB code
3fub
Structure name
crystal structure of gdnf-gfralpha1 complex
Structure deposition date
2009-01-14
Thiol separation (Å)
6
Half-sphere exposure sum ?
46
Minimum pKa ?
9
% buried
nan
Peptide accession
P39905
Residue number A
149
Residue number B
178
Peptide name
Glial cell line-derived neurotrophic factor

Ligandability

Cysteine 149 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 178 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glial cell line-derived neurotrophic factor between cysteines 208 and 210 (132 and 134 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
1agq
Structure name
glial cell-derived neurotrophic factor from rat
Structure deposition date
1997-03-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07731
Residue number A
208
Residue number B
210
Peptide name
Glial cell line-derived neurotrophic factor

Ligandability

Cysteine 208 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 210 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glial cell line-derived neurotrophic factor between cysteines 149 and 208 (72 and 131 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
3fub
Structure name
crystal structure of gdnf-gfralpha1 complex
Structure deposition date
2009-01-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P39905
Residue number A
149
Residue number B
208
Peptide name
Glial cell line-derived neurotrophic factor

Ligandability

Cysteine 149 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 208 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glial cell line-derived neurotrophic factor between cysteines 118 and 178 (41 and 101 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
2v5e
Structure name
the structure of the gdnf:coreceptor complex: insights into ret signalling and heparin binding
Structure deposition date
2008-10-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
54
Minimum pKa ?
9
% buried
nan
Peptide accession
P39905
Residue number A
118
Residue number B
178
Peptide name
Glial cell line-derived neurotrophic factor

Ligandability

Cysteine 118 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 178 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glial cell line-derived neurotrophic factor between cysteines 145 and 149 (68 and 72 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
3fub
Structure name
crystal structure of gdnf-gfralpha1 complex
Structure deposition date
2009-01-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P39905
Residue number A
145
Residue number B
149
Peptide name
Glial cell line-derived neurotrophic factor

Ligandability

Cysteine 145 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 149 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glial cell line-derived neurotrophic factor between cysteines 178 and 210 (101 and 133 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
3fub
Structure name
crystal structure of gdnf-gfralpha1 complex
Structure deposition date
2009-01-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
49
Minimum pKa ?
9
% buried
nan
Peptide accession
P39905
Residue number A
178
Residue number B
210
Peptide name
Glial cell line-derived neurotrophic factor

Ligandability

Cysteine 178 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 210 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glial cell line-derived neurotrophic factor between cysteines 145 and 210 (68 and 133 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
3fub
Structure name
crystal structure of gdnf-gfralpha1 complex
Structure deposition date
2009-01-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P39905
Residue number A
145
Residue number B
210
Peptide name
Glial cell line-derived neurotrophic factor

Ligandability

Cysteine 145 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 210 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glial cell line-derived neurotrophic factor between cysteines 178 and 179 (101 and 102 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
3fub
Structure name
crystal structure of gdnf-gfralpha1 complex
Structure deposition date
2009-01-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
48
Minimum pKa ?
9
% buried
nan
Peptide accession
P39905
Residue number A
178
Residue number B
179
Peptide name
Glial cell line-derived neurotrophic factor

Ligandability

Cysteine 178 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 179 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glial cell line-derived neurotrophic factor between cysteines 145 and 178 (68 and 101 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
2v5e
Structure name
the structure of the gdnf:coreceptor complex: insights into ret signalling and heparin binding
Structure deposition date
2008-10-03
Thiol separation (Å)
10
Half-sphere exposure sum ?
57
Minimum pKa ?
9
% buried
nan
Peptide accession
P39905
Residue number A
145
Residue number B
178
Peptide name
Glial cell line-derived neurotrophic factor

Ligandability

Cysteine 145 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 178 of Glial cell line-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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