ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interleukin-6 receptor subunit beta

Intermolecular
Cysteine 419 and cysteine 419
Intramolecular
Cysteine 48 and cysteine 103
Cysteine 28 and cysteine 54
Cysteine 458 and cysteine 466
Cysteine 172 and cysteine 182
Cysteine 134 and cysteine 144
Cysteine 144 and cysteine 172
Cysteine 28 and cysteine 103
Cysteine 134 and cysteine 182
Cysteine 144 and cysteine 182
More...
Cysteine 48 and cysteine 54
Cysteine 134 and cysteine 172
Cysteine 466 and cysteine 491
Cysteine 28 and cysteine 48
Cysteine 54 and cysteine 103
Cysteine 458 and cysteine 491
A redox-regulated disulphide may form between two units of Interleukin-6 receptor subunit beta at cysteines 419 and 419 (397 and 397 respectively in this structure).

Details

Redox score ?
82
PDB code
3l5j
Structure name
crystal structure of fniii domains of human gp130 (domains 4-6)
Structure deposition date
2009-12-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide A name
Interleukin-6 receptor subunit beta
Peptide B name
Interleukin-6 receptor subunit beta
Peptide A accession
P40189
Peptide B accession
P40189
Peptide A residue number
419
Peptide B residue number
419

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-6 receptor subunit beta between cysteines 48 and 103 (26 and 81 respectively in this structure).

Details

Redox score ?
88
PDB code
3l5h
Structure name
crystal structure of the full ectodomain of human gp130: new insights into the molecular assembly of receptor complexes
Structure deposition date
2009-12-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P40189
Residue number A
48
Residue number B
103
Peptide name
Interleukin-6 receptor subunit beta

Ligandability

Cysteine 48 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 103 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-6 receptor subunit beta between cysteines 28 and 54 (6 and 32 respectively in this structure).

Details

Redox score ?
85
PDB code
3l5h
Structure name
crystal structure of the full ectodomain of human gp130: new insights into the molecular assembly of receptor complexes
Structure deposition date
2009-12-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
P40189
Residue number A
28
Residue number B
54
Peptide name
Interleukin-6 receptor subunit beta

Ligandability

Cysteine 28 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 54 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-6 receptor subunit beta between cysteines 458 and 466 (436 and 444 respectively in this structure).

Details

Redox score ?
84
PDB code
3l5j
Structure name
crystal structure of fniii domains of human gp130 (domains 4-6)
Structure deposition date
2009-12-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
P40189
Residue number A
458
Residue number B
466
Peptide name
Interleukin-6 receptor subunit beta

Ligandability

Cysteine 458 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 466 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-6 receptor subunit beta between cysteines 172 and 182 (150 and 160 respectively in this structure).

Details

Redox score ?
84
PDB code
1p9m
Structure name
crystal structure of the hexameric human il-6/il-6 alpha receptor/gp130 complex
Structure deposition date
2003-05-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P40189
Residue number A
172
Residue number B
182
Peptide name
Interleukin-6 receptor subunit beta

Ligandability

Cysteine 172 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 182 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-6 receptor subunit beta between cysteines 134 and 144 (16 and 26 respectively in this structure).

Details

Redox score ?
83
PDB code
1bqu
Structure name
cytokyne-binding region of gp130
Structure deposition date
1998-08-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P40189
Residue number A
134
Residue number B
144
Peptide name
Interleukin-6 receptor subunit beta

Ligandability

Cysteine 134 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 144 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-6 receptor subunit beta between cysteines 144 and 172 (26 and 54 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
1bqu
Structure name
cytokyne-binding region of gp130
Structure deposition date
1998-08-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P40189
Residue number A
144
Residue number B
172
Peptide name
Interleukin-6 receptor subunit beta

Ligandability

Cysteine 144 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 172 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-6 receptor subunit beta between cysteines 28 and 103 (6 and 81 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
1i1r
Structure name
crystal structure of a cytokine/receptor complex
Structure deposition date
2001-02-02
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P40189
Residue number A
28
Residue number B
103
Peptide name
Interleukin-6 receptor subunit beta

Ligandability

Cysteine 28 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 103 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-6 receptor subunit beta between cysteines 134 and 182 (112 and 160 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
3l5h
Structure name
crystal structure of the full ectodomain of human gp130: new insights into the molecular assembly of receptor complexes
Structure deposition date
2009-12-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P40189
Residue number A
134
Residue number B
182
Peptide name
Interleukin-6 receptor subunit beta

Ligandability

Cysteine 134 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 182 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-6 receptor subunit beta between cysteines 144 and 182 (122 and 160 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
1pvh
Structure name
crystal structure of leukemia inhibitory factor in complex with gp130
Structure deposition date
2003-06-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P40189
Residue number A
144
Residue number B
182
Peptide name
Interleukin-6 receptor subunit beta

Ligandability

Cysteine 144 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 182 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-6 receptor subunit beta between cysteines 48 and 54 (26 and 32 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
3l5h
Structure name
crystal structure of the full ectodomain of human gp130: new insights into the molecular assembly of receptor complexes
Structure deposition date
2009-12-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P40189
Residue number A
48
Residue number B
54
Peptide name
Interleukin-6 receptor subunit beta

Ligandability

Cysteine 48 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 54 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-6 receptor subunit beta between cysteines 134 and 172 (112 and 150 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
3l5h
Structure name
crystal structure of the full ectodomain of human gp130: new insights into the molecular assembly of receptor complexes
Structure deposition date
2009-12-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P40189
Residue number A
134
Residue number B
172
Peptide name
Interleukin-6 receptor subunit beta

Ligandability

Cysteine 134 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 172 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-6 receptor subunit beta between cysteines 466 and 491 (444 and 469 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
3l5h
Structure name
crystal structure of the full ectodomain of human gp130: new insights into the molecular assembly of receptor complexes
Structure deposition date
2009-12-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
52
Minimum pKa ?
11
% buried
nan
Peptide accession
P40189
Residue number A
466
Residue number B
491
Peptide name
Interleukin-6 receptor subunit beta

Ligandability

Cysteine 466 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 491 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-6 receptor subunit beta between cysteines 28 and 48 (6 and 26 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
1p9m
Structure name
crystal structure of the hexameric human il-6/il-6 alpha receptor/gp130 complex
Structure deposition date
2003-05-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P40189
Residue number A
28
Residue number B
48
Peptide name
Interleukin-6 receptor subunit beta

Ligandability

Cysteine 28 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 48 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-6 receptor subunit beta between cysteines 54 and 103 (32 and 81 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
1i1r
Structure name
crystal structure of a cytokine/receptor complex
Structure deposition date
2001-02-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P40189
Residue number A
54
Residue number B
103
Peptide name
Interleukin-6 receptor subunit beta

Ligandability

Cysteine 54 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 103 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-6 receptor subunit beta between cysteines 458 and 491 (436 and 469 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
3l5i
Structure name
crystal structure of fniii domains of human gp130 (domains 4-6)
Structure deposition date
2009-12-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
nan
Peptide accession
P40189
Residue number A
458
Residue number B
491
Peptide name
Interleukin-6 receptor subunit beta

Ligandability

Cysteine 458 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 491 of Interleukin-6 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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